Abstract
Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degradespecific bonds within the bacterial cell wall. These enzymes represent a novel classof antibacterial agents against infectious pathogens, especially in light of multidrugresistantbacteria, which have made antibiotic therapy increasingly redundant. Lysinshave been used successfully to eliminate/control bacterial pathogens in variousanatomical locations in mouse and other animal models. Engineering tactics have alsobeen successfully applied to improve lysin function. This review discusses the structureand function of lysins. It highlights protein-engineering tactics utilised to improvelysin activity. It also reviews the applications of lysins towards food biopreservation, therapeutics, biofilm elimination and diagnostics.
| Original language | English |
|---|---|
| Pages (from-to) | 183-199 |
| Number of pages | 17 |
| Journal | Science Progress |
| Volume | 99 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 12 Responsible Consumption and Production
Keywords
- Antibacterial
- Bacteriophage
- Detection
- Endolysin
- Lysis
- Protein engineering
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