Baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane

Rebecca E. Deasy; Noreen O'Riordan; Anita R. Maguire

doi:10.3390/catal4020186

Baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane

Rebecca E. Deasy
, Noreen O'Riordan
, Anita R. Maguire

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (≤25%) and diastereocontrol.

Original language	English
Pages (from-to)	186-195
Number of pages	10
Journal	Catalysts
Volume	4
Issue number	2
DOIs	https://doi.org/10.3390/catal4020186
Publication status	Published - 18 Jun 2014

Keywords

Asymmetric reduction
Baker's yeast (Saccharomyces cerevisiae)
Biocatalysis
Chiral alcohol
Sulfolane

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10.3390/catal4020186

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title = "Baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane",

abstract = "The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98\% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (≤25\%) and diastereocontrol.",

keywords = "Asymmetric reduction, Baker's yeast (Saccharomyces cerevisiae), Biocatalysis, Chiral alcohol, Sulfolane",

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year = "2014",

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language = "English",

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journal = "Catalysts",

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AU - Deasy, Rebecca E.

AU - O'Riordan, Noreen

AU - Maguire, Anita R.

PY - 2014/6/18

Y1 - 2014/6/18

N2 - The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (≤25%) and diastereocontrol.

AB - The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (≤25%) and diastereocontrol.

KW - Asymmetric reduction

KW - Baker's yeast (Saccharomyces cerevisiae)

KW - Biocatalysis

KW - Chiral alcohol

KW - Sulfolane

UR - https://www.scopus.com/pages/publications/84906851058

U2 - 10.3390/catal4020186

DO - 10.3390/catal4020186

M3 - Article

AN - SCOPUS:84906851058

SN - 2073-4344

VL - 4

SP - 186

EP - 195

JO - Catalysts

JF - Catalysts

IS - 2

ER -

Baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane

Abstract

Keywords

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