Beyond the symptom: the biology of fatigue

David M. Raizen; Janet Mullington; Christelle Anaclet; Gerard Clarke; Hugo Critchley; Robert Dantzer; Ronald Davis; Kelly L. Drew; Josh Fessel; Patrick M. Fuller; Erin M. Gibson; Mary Harrington; W. Ian Lipkin; Elizabeth B. Klerman; Nancy Klimas; Anthony L. Komaroff; Walter Koroshetz; Lauren Krupp; Anna Kuppuswamy; Julie Lasselin; Laura D. Lewis; Pierre J. Magistretti; Heidi Y. Matos; Christine Miaskowski; Andrew H. Miller; Avindra Nath; Maiken Nedergaard; Mark R. Opp; Marylyn D. Ritchie; Dragana Rogulja; Asya Rolls; John D. Salamone; Clifford Saper; Vicky Whittemore; Glenn Wylie; Jarred Younger; Phyllis C. Zee; H. Craig Heller

doi:10.1093/sleep/zsad069

Beyond the symptom: the biology of fatigue

David M. Raizen
, Janet Mullington
, Christelle Anaclet
, Gerard Clarke
, Hugo Critchley
, Robert Dantzer
, Ronald Davis
, Kelly L. Drew
, Josh Fessel
, Patrick M. Fuller
, Erin M. Gibson
, Mary Harrington
, W. Ian Lipkin
, Elizabeth B. Klerman
, Nancy Klimas
, Anthony L. Komaroff
, Walter Koroshetz
, Lauren Krupp
, Anna Kuppuswamy
, Julie Lasselin

Laura D. Lewis, Pierre J. Magistretti, Heidi Y. Matos, Christine Miaskowski, Andrew H. Miller, Avindra Nath, Maiken Nedergaard, Mark R. Opp, Marylyn D. Ritchie, Dragana Rogulja, Asya Rolls, John D. Salamone, Clifford Saper, Vicky Whittemore, Glenn Wylie, Jarred Younger, Phyllis C. Zee, H. Craig Heller

University of Pennsylvania
University of California at Davis
University of Sussex
University of Texas MD Anderson Cancer Center
Stanford University
University of Alaska Fairbanks
National Institutes of Health
Smith College
Columbia University
Harvard University
Nova Southeastern University
New York University
University College London
Stockholm University
Boston University
King Abdullah University of Science and Technology
University of California at San Francisco
Emory University
University of Rochester
University of Colorado Boulder
Technion-Israel Institute of Technology
University of Connecticut
Kessler Foundation
University of Alabama at Birmingham
Northwestern University

Research output: Contribution to journal › Review article › peer-review

Abstract

A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Original language	English
Journal	Sleep
Volume	46
Issue number	9
DOIs	https://doi.org/10.1093/sleep/zsad069
Publication status	Published - 1 Sep 2023

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10.1093/sleep/zsad069

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Raizen, D. M., Mullington, J., Anaclet, C., Clarke, G., Critchley, H., Dantzer, R., Davis, R., Drew, K. L., Fessel, J., Fuller, P. M., Gibson, E. M., Harrington, M., Lipkin, W. I., Klerman, E. B., Klimas, N., Komaroff, A. L., Koroshetz, W., Krupp, L., Kuppuswamy, A., ... Heller, H. C. (2023). Beyond the symptom: the biology of fatigue. Sleep, 46(9). https://doi.org/10.1093/sleep/zsad069

@article{282c72c4ab5949abb7e1d27cdc2eb68b,

title = "Beyond the symptom: the biology of fatigue",

abstract = "A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.",

author = "Raizen, \{David M.\} and Janet Mullington and Christelle Anaclet and Gerard Clarke and Hugo Critchley and Robert Dantzer and Ronald Davis and Drew, \{Kelly L.\} and Josh Fessel and Fuller, \{Patrick M.\} and Gibson, \{Erin M.\} and Mary Harrington and Lipkin, \{W. Ian\} and Klerman, \{Elizabeth B.\} and Nancy Klimas and Komaroff, \{Anthony L.\} and Walter Koroshetz and Lauren Krupp and Anna Kuppuswamy and Julie Lasselin and Lewis, \{Laura D.\} and Magistretti, \{Pierre J.\} and Matos, \{Heidi Y.\} and Christine Miaskowski and Miller, \{Andrew H.\} and Avindra Nath and Maiken Nedergaard and Opp, \{Mark R.\} and Ritchie, \{Marylyn D.\} and Dragana Rogulja and Asya Rolls and Salamone, \{John D.\} and Clifford Saper and Vicky Whittemore and Glenn Wylie and Jarred Younger and Zee, \{Phyllis C.\} and Heller, \{H. Craig\}",

year = "2023",

month = sep,

day = "1",

doi = "10.1093/sleep/zsad069",

language = "English",

volume = "46",

journal = "Sleep",

issn = "0161-8105",

publisher = "Oxford University Press",

number = "9",

}

Raizen, DM, Mullington, J, Anaclet, C, Clarke, G, Critchley, H, Dantzer, R, Davis, R, Drew, KL, Fessel, J, Fuller, PM, Gibson, EM, Harrington, M, Lipkin, WI, Klerman, EB, Klimas, N, Komaroff, AL, Koroshetz, W, Krupp, L, Kuppuswamy, A, Lasselin, J, Lewis, LD, Magistretti, PJ, Matos, HY, Miaskowski, C, Miller, AH, Nath, A, Nedergaard, M, Opp, MR, Ritchie, MD, Rogulja, D, Rolls, A, Salamone, JD, Saper, C, Whittemore, V, Wylie, G, Younger, J, Zee, PC & Heller, HC 2023, 'Beyond the symptom: the biology of fatigue', Sleep, vol. 46, no. 9. https://doi.org/10.1093/sleep/zsad069

TY - JOUR

T1 - Beyond the symptom

T2 - the biology of fatigue

AU - Raizen, David M.

AU - Mullington, Janet

AU - Anaclet, Christelle

AU - Clarke, Gerard

AU - Critchley, Hugo

AU - Dantzer, Robert

AU - Davis, Ronald

AU - Drew, Kelly L.

AU - Fessel, Josh

AU - Fuller, Patrick M.

AU - Gibson, Erin M.

AU - Harrington, Mary

AU - Lipkin, W. Ian

AU - Klerman, Elizabeth B.

AU - Klimas, Nancy

AU - Komaroff, Anthony L.

AU - Koroshetz, Walter

AU - Krupp, Lauren

AU - Kuppuswamy, Anna

AU - Lasselin, Julie

AU - Lewis, Laura D.

AU - Magistretti, Pierre J.

AU - Matos, Heidi Y.

AU - Miaskowski, Christine

AU - Miller, Andrew H.

AU - Nath, Avindra

AU - Nedergaard, Maiken

AU - Opp, Mark R.

AU - Ritchie, Marylyn D.

AU - Rogulja, Dragana

AU - Rolls, Asya

AU - Salamone, John D.

AU - Saper, Clifford

AU - Whittemore, Vicky

AU - Wylie, Glenn

AU - Younger, Jarred

AU - Zee, Phyllis C.

AU - Heller, H. Craig

PY - 2023/9/1

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N2 - A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

AB - A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

UR - https://www.scopus.com/pages/publications/85162254753

U2 - 10.1093/sleep/zsad069

DO - 10.1093/sleep/zsad069

M3 - Review article

C2 - 37224457

AN - SCOPUS:85162254753

SN - 0161-8105

VL - 46

JO - Sleep

JF - Sleep

IS - 9

ER -

Beyond the symptom: the biology of fatigue

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