Biased Opioid Receptor Ligands: Gain without Pain

Ravi Ranjan; Shubhi Pandey; Arun K. Shukla

doi:10.1016/j.tem.2017.01.001

Biased Opioid Receptor Ligands: Gain without Pain

Ravi Ranjan
, Shubhi Pandey
, Arun K. Shukla

Indian Institute of Technology Kanpur

Research output: Contribution to journal › Short survey › peer-review

Abstract

Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.

Original language	English
Pages (from-to)	247-249
Number of pages	3
Journal	Trends in Endocrinology and Metabolism
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.tem.2017.01.001
Publication status	Published - 1 Apr 2017
Externally published	Yes

Access to Document

10.1016/j.tem.2017.01.001

Cite this

@article{1ef91280b4e34ccab2c984ac0bdd7494,

title = "Biased Opioid Receptor Ligands: Gain without Pain",

abstract = "Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.",

author = "Ravi Ranjan and Shubhi Pandey and Shukla, \{Arun K.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = apr,

day = "1",

doi = "10.1016/j.tem.2017.01.001",

language = "English",

volume = "28",

pages = "247--249",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Biased Opioid Receptor Ligands

T2 - Gain without Pain

AU - Ranjan, Ravi

AU - Pandey, Shubhi

AU - Shukla, Arun K.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.

AB - Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.

UR - https://www.scopus.com/pages/publications/85009476453

U2 - 10.1016/j.tem.2017.01.001

DO - 10.1016/j.tem.2017.01.001

M3 - Short survey

C2 - 28110810

AN - SCOPUS:85009476453

SN - 1043-2760

VL - 28

SP - 247

EP - 249

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 4

ER -

Biased Opioid Receptor Ligands: Gain without Pain

Abstract

Access to Document

Other files and links

Fingerprint

Cite this