TY - JOUR
T1 - Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury
AU - Duranti, Sabrina
AU - Vivo, Valentina
AU - Zini, Irene
AU - Milani, Christian
AU - Mangifesta, Marta
AU - Anzalone, Rosaria
AU - Mancabelli, Leonardo
AU - Viappiani, Alice
AU - Cantoni, Anna Maria
AU - Barocelli, Elisabetta
AU - Van Sinderen, Douwe
AU - Bertoni, Simona
AU - Turroni, Francesca
N1 - Publisher Copyright:
© 2018 Duranti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/8
Y1 - 2018/8
N2 - Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/ reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.
AB - Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/ reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.
UR - https://www.scopus.com/pages/publications/85052811904
U2 - 10.1371/journal.pone.0202670
DO - 10.1371/journal.pone.0202670
M3 - Article
C2 - 30161157
AN - SCOPUS:85052811904
SN - 1932-6203
VL - 13
JO - PLOS ONE
JF - PLOS ONE
IS - 8
M1 - e0202670
ER -