BIFIDOBACTERIUM LONGUM FOR TREATING OBESITY AND WEIGHT MANAGEMENT

Roy Bernard; John Cryan; Ted Dinan; Catherine Stanton; Cristina Torres

BIFIDOBACTERIUM LONGUM FOR TREATING OBESITY AND WEIGHT MANAGEMENT

Roy Bernard (Inventor)
, John Cryan (Inventor)
, Ted Dinan (Inventor)
, Catherine Stanton (Inventor)
, Cristina Torres (Inventor)

Teagasc - Irish Agriculture and Food Development Authority

Research output: Patent

Abstract

A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.

Original language	English
Patent number	US2020281992
IPC	A61P 3/ 10 A I
Priority date	27/08/18
Publication status	Published - 10 Sep 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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abstract = "A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.",

author = "Roy Bernard and John Cryan and Ted Dinan and Catherine Stanton and Cristina Torres",

year = "2020",

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language = "English",

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AU - Bernard, Roy

AU - Cryan, John

AU - Dinan, Ted

AU - Stanton, Catherine

AU - Torres, Cristina

PY - 2020/9/10

Y1 - 2020/9/10

N2 - A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.

AB - A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.

M3 - Patent

M1 - US2020281992

ER -

BIFIDOBACTERIUM LONGUM FOR TREATING OBESITY AND WEIGHT MANAGEMENT

Abstract

UN SDGs

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