TY - JOUR
T1 - Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior
AU - Gee, Christine E.
AU - Peterlik, Daniel
AU - Neuhäuser, Christoph
AU - Bouhelal, Rochdi
AU - Kaupmann, Klemens
AU - Laue, Grit
AU - Uschold-Schmidt, Nicole
AU - Feuerbach, Dominik
AU - Zimmermann, Kaspar
AU - Ofner, Silvio
AU - Cryan, John F.
AU - Van Der Putten, Herman
AU - Fendt, Markus
AU - Vranesic, Ivo
AU - Glatthar, Ralf
AU - Flor, Peter J.
PY - 2014/4/18
Y1 - 2014/4/18
N2 - Background: Behavioral genetics identified mGlu7 as a key regulator of brain emotion circuits. Results: An mGlu7-selective, Venus flytrap domain (VFTD)-directed antagonist inhibits fear, synaptic plasticity, stress, and anxiety in rodents. Conclusion: Pharmacological blockers of mGlu7 may represent promising future anxiolytics and antidepressants in man. Significance: The VFTD region of class C GPCRs provides a promising target for computer-assisted drug design.
AB - Background: Behavioral genetics identified mGlu7 as a key regulator of brain emotion circuits. Results: An mGlu7-selective, Venus flytrap domain (VFTD)-directed antagonist inhibits fear, synaptic plasticity, stress, and anxiety in rodents. Conclusion: Pharmacological blockers of mGlu7 may represent promising future anxiolytics and antidepressants in man. Significance: The VFTD region of class C GPCRs provides a promising target for computer-assisted drug design.
UR - https://www.scopus.com/pages/publications/84899024860
U2 - 10.1074/jbc.M113.542654
DO - 10.1074/jbc.M113.542654
M3 - Article
C2 - 24596089
AN - SCOPUS:84899024860
SN - 0021-9258
VL - 289
SP - 10975
EP - 10987
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 16
ER -
