Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

Christine E. Gee; Daniel Peterlik; Christoph Neuhäuser; Rochdi Bouhelal; Klemens Kaupmann; Grit Laue; Nicole Uschold-Schmidt; Dominik Feuerbach; Kaspar Zimmermann; Silvio Ofner; John F. Cryan; Herman Van Der Putten; Markus Fendt; Ivo Vranesic; Ralf Glatthar; Peter J. Flor

doi:10.1074/jbc.M113.542654

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

Christine E. Gee
, Daniel Peterlik
, Christoph Neuhäuser
, Rochdi Bouhelal
, Klemens Kaupmann
, Grit Laue
, Nicole Uschold-Schmidt
, Dominik Feuerbach
, Kaspar Zimmermann
, Silvio Ofner
, John F. Cryan
, Herman Van Der Putten
, Markus Fendt
, Ivo Vranesic
, Ralf Glatthar
, Peter J. Flor

Novartis
University of Hamburg
University of Regensburg
Otto von Guericke University Magdeburg

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Behavioral genetics identified mGlu7 as a key regulator of brain emotion circuits. Results: An mGlu7-selective, Venus flytrap domain (VFTD)-directed antagonist inhibits fear, synaptic plasticity, stress, and anxiety in rodents. Conclusion: Pharmacological blockers of mGlu7 may represent promising future anxiolytics and antidepressants in man. Significance: The VFTD region of class C GPCRs provides a promising target for computer-assisted drug design.

Original language	English
Pages (from-to)	10975-10987
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.542654
Publication status	Published - 18 Apr 2014

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10.1074/jbc.M113.542654

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Gee, C. E., Peterlik, D., Neuhäuser, C., Bouhelal, R., Kaupmann, K., Laue, G., Uschold-Schmidt, N., Feuerbach, D., Zimmermann, K., Ofner, S., Cryan, J. F., Van Der Putten, H., Fendt, M., Vranesic, I., Glatthar, R., & Flor, P. J. (2014). Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. Journal of Biological Chemistry, 289(16), 10975-10987. https://doi.org/10.1074/jbc.M113.542654

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title = "Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior",

abstract = "Background: Behavioral genetics identified mGlu7 as a key regulator of brain emotion circuits. Results: An mGlu7-selective, Venus flytrap domain (VFTD)-directed antagonist inhibits fear, synaptic plasticity, stress, and anxiety in rodents. Conclusion: Pharmacological blockers of mGlu7 may represent promising future anxiolytics and antidepressants in man. Significance: The VFTD region of class C GPCRs provides a promising target for computer-assisted drug design.",

author = "Gee, \{Christine E.\} and Daniel Peterlik and Christoph Neuh{\"a}user and Rochdi Bouhelal and Klemens Kaupmann and Grit Laue and Nicole Uschold-Schmidt and Dominik Feuerbach and Kaspar Zimmermann and Silvio Ofner and Cryan, \{John F.\} and \{Van Der Putten\}, Herman and Markus Fendt and Ivo Vranesic and Ralf Glatthar and Flor, \{Peter J.\}",

year = "2014",

month = apr,

day = "18",

doi = "10.1074/jbc.M113.542654",

language = "English",

volume = "289",

pages = "10975--10987",

journal = "Journal of Biological Chemistry",

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number = "16",

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Gee, CE, Peterlik, D, Neuhäuser, C, Bouhelal, R, Kaupmann, K, Laue, G, Uschold-Schmidt, N, Feuerbach, D, Zimmermann, K, Ofner, S, Cryan, JF, Van Der Putten, H, Fendt, M, Vranesic, I, Glatthar, R & Flor, PJ 2014, 'Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior', Journal of Biological Chemistry, vol. 289, no. 16, pp. 10975-10987. https://doi.org/10.1074/jbc.M113.542654

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. / Gee, Christine E.; Peterlik, Daniel; Neuhäuser, Christoph et al.
In: Journal of Biological Chemistry, Vol. 289, No. 16, 18.04.2014, p. 10975-10987.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

AU - Gee, Christine E.

AU - Peterlik, Daniel

AU - Neuhäuser, Christoph

AU - Bouhelal, Rochdi

AU - Kaupmann, Klemens

AU - Laue, Grit

AU - Uschold-Schmidt, Nicole

AU - Feuerbach, Dominik

AU - Zimmermann, Kaspar

AU - Ofner, Silvio

AU - Cryan, John F.

AU - Van Der Putten, Herman

AU - Fendt, Markus

AU - Vranesic, Ivo

AU - Glatthar, Ralf

AU - Flor, Peter J.

PY - 2014/4/18

Y1 - 2014/4/18

N2 - Background: Behavioral genetics identified mGlu7 as a key regulator of brain emotion circuits. Results: An mGlu7-selective, Venus flytrap domain (VFTD)-directed antagonist inhibits fear, synaptic plasticity, stress, and anxiety in rodents. Conclusion: Pharmacological blockers of mGlu7 may represent promising future anxiolytics and antidepressants in man. Significance: The VFTD region of class C GPCRs provides a promising target for computer-assisted drug design.

AB - Background: Behavioral genetics identified mGlu7 as a key regulator of brain emotion circuits. Results: An mGlu7-selective, Venus flytrap domain (VFTD)-directed antagonist inhibits fear, synaptic plasticity, stress, and anxiety in rodents. Conclusion: Pharmacological blockers of mGlu7 may represent promising future anxiolytics and antidepressants in man. Significance: The VFTD region of class C GPCRs provides a promising target for computer-assisted drug design.

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DO - 10.1074/jbc.M113.542654

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AN - SCOPUS:84899024860

SN - 0021-9258

VL - 289

SP - 10975

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 16

ER -

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

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