TY - JOUR
T1 - Blood gas measures as predictors for neonatal encephalopathy severity
AU - Sakpichaisakul, Kullasate
AU - Supapannachart, Krittin J.
AU - El-DIb, Mohamed
AU - Szakmar, Eniko
AU - Yang, Edward
AU - Walsh, Brain H.
AU - Robinson, Julian N.
AU - Cherkerzian, Sara
AU - Volpe, Joseph J.
AU - Inder, Terrie E.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/9
Y1 - 2021/9
N2 - Objective: To correlate arterial umbilical cord gas (aUCG) and infant blood gas with severity of neurological injury. Study design: Retrospective single-site study of infants evaluated for therapeutic hypothermia. Clinical neurological examination and a validated MRI scoring system were used to assess injury severity. Results: Sixty-eight infants were included. aUCG base deficit (BD) and lactate correlated with infant blood gas counterparts (r = 0.43 and r = 0.56, respectively). aUCG and infant pH did not correlate. Infant blood gas lactate (RADJ2 = 0.40), infant BD (RADJ2 = 0.26), infant pH (RADJ2 = 0.17), aUCG base deficit (RADJ2 = 0.08), and aUCG lactate (RADJ2 = 0.11) were associated with clinical neurological examination severity. aUCG and infant blood gas measures were not correlated with MRI score. Conclusion: Metabolic measures from initial infant blood gases were most associated with the clinical neurological examination severity and can be used to evaluate hypoxic-ischemic cerebral injury risk.
AB - Objective: To correlate arterial umbilical cord gas (aUCG) and infant blood gas with severity of neurological injury. Study design: Retrospective single-site study of infants evaluated for therapeutic hypothermia. Clinical neurological examination and a validated MRI scoring system were used to assess injury severity. Results: Sixty-eight infants were included. aUCG base deficit (BD) and lactate correlated with infant blood gas counterparts (r = 0.43 and r = 0.56, respectively). aUCG and infant pH did not correlate. Infant blood gas lactate (RADJ2 = 0.40), infant BD (RADJ2 = 0.26), infant pH (RADJ2 = 0.17), aUCG base deficit (RADJ2 = 0.08), and aUCG lactate (RADJ2 = 0.11) were associated with clinical neurological examination severity. aUCG and infant blood gas measures were not correlated with MRI score. Conclusion: Metabolic measures from initial infant blood gases were most associated with the clinical neurological examination severity and can be used to evaluate hypoxic-ischemic cerebral injury risk.
UR - https://www.scopus.com/pages/publications/85108620447
U2 - 10.1038/s41372-021-01075-w
DO - 10.1038/s41372-021-01075-w
M3 - Article
C2 - 34168288
AN - SCOPUS:85108620447
SN - 0743-8346
VL - 41
SP - 2261
EP - 2269
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 9
ER -
