Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use

Sanathana Konugolu Venkata Sekar; Alberto Dalla Mora; Ilaria Bargigia; Edoardo Martinenghi; Claus Lindner; Parisa Farzam; Marco Pagliazzi; Turgut Durduran; Paola Taroni; Antonio Pifferi; Andrea Farina

doi:10.1109/JSTQE.2015.2506613

Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use

Sanathana Konugolu Venkata Sekar
, Alberto Dalla Mora
, Ilaria Bargigia
, Edoardo Martinenghi
, Claus Lindner
, Parisa Farzam
, Marco Pagliazzi
, Turgut Durduran
, Paola Taroni
, Antonio Pifferi
, Andrea Farina

Polytechnic University of Milan
Italian Institute of Technology
Barcelona Institute of Science and Technology
ICREA
National Research Council of Italy

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the design, development, and performance assessment of a portable time-resolved system measuring absorption and scattering spectra of highly diffusive media over the 600-1350 nm range. In view of clinical use, two strategies were implemented; the first one equips the system with high responsivity in key tissue absorbing regions, whereas the second one makes the system immune to time drift. The MEDPHOT protocol was used for the performance assessment of the instrument. Finally, the system was enrolled into its first in vivo trial phase, measuring the broadband absorption and scattering spectra of human manubrium, abdomen fat tissues, and forehead for the in vivo quantification of key tissue constituents.

Original language	English
Article number	7349112
Pages (from-to)	406-414
Number of pages	9
Journal	IEEE Journal of Selected Topics in Quantum Electronics
Volume	22
Issue number	3
DOIs	https://doi.org/10.1109/JSTQE.2015.2506613
Publication status	Published - 1 May 2016
Externally published	Yes

Keywords

Absorption
Broadband
Diffuse Optics
In-vivo
Scattering
Silicon Photomultiplier (SiPM)
Time-Resolved
Turbid media

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10.1109/JSTQE.2015.2506613

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Konugolu Venkata Sekar, S., Dalla Mora, A., Bargigia, I., Martinenghi, E., Lindner, C., Farzam, P., Pagliazzi, M., Durduran, T., Taroni, P., Pifferi, A., & Farina, A. (2016). Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use. IEEE Journal of Selected Topics in Quantum Electronics, 22(3), 406-414. Article 7349112. https://doi.org/10.1109/JSTQE.2015.2506613

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title = "Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use",

abstract = "We report on the design, development, and performance assessment of a portable time-resolved system measuring absorption and scattering spectra of highly diffusive media over the 600-1350 nm range. In view of clinical use, two strategies were implemented; the first one equips the system with high responsivity in key tissue absorbing regions, whereas the second one makes the system immune to time drift. The MEDPHOT protocol was used for the performance assessment of the instrument. Finally, the system was enrolled into its first in vivo trial phase, measuring the broadband absorption and scattering spectra of human manubrium, abdomen fat tissues, and forehead for the in vivo quantification of key tissue constituents.",

keywords = "Absorption, Broadband, Diffuse Optics, In-vivo, Scattering, Silicon Photomultiplier (SiPM), Time-Resolved, Turbid media",

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doi = "10.1109/JSTQE.2015.2506613",

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Konugolu Venkata Sekar, S, Dalla Mora, A, Bargigia, I, Martinenghi, E, Lindner, C, Farzam, P, Pagliazzi, M, Durduran, T, Taroni, P, Pifferi, A & Farina, A 2016, 'Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use', IEEE Journal of Selected Topics in Quantum Electronics, vol. 22, no. 3, 7349112, pp. 406-414. https://doi.org/10.1109/JSTQE.2015.2506613

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T1 - Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use

AU - Konugolu Venkata Sekar, Sanathana

AU - Dalla Mora, Alberto

AU - Bargigia, Ilaria

AU - Martinenghi, Edoardo

AU - Lindner, Claus

AU - Farzam, Parisa

AU - Pagliazzi, Marco

AU - Durduran, Turgut

AU - Taroni, Paola

AU - Pifferi, Antonio

AU - Farina, Andrea

PY - 2016/5/1

Y1 - 2016/5/1

N2 - We report on the design, development, and performance assessment of a portable time-resolved system measuring absorption and scattering spectra of highly diffusive media over the 600-1350 nm range. In view of clinical use, two strategies were implemented; the first one equips the system with high responsivity in key tissue absorbing regions, whereas the second one makes the system immune to time drift. The MEDPHOT protocol was used for the performance assessment of the instrument. Finally, the system was enrolled into its first in vivo trial phase, measuring the broadband absorption and scattering spectra of human manubrium, abdomen fat tissues, and forehead for the in vivo quantification of key tissue constituents.

AB - We report on the design, development, and performance assessment of a portable time-resolved system measuring absorption and scattering spectra of highly diffusive media over the 600-1350 nm range. In view of clinical use, two strategies were implemented; the first one equips the system with high responsivity in key tissue absorbing regions, whereas the second one makes the system immune to time drift. The MEDPHOT protocol was used for the performance assessment of the instrument. Finally, the system was enrolled into its first in vivo trial phase, measuring the broadband absorption and scattering spectra of human manubrium, abdomen fat tissues, and forehead for the in vivo quantification of key tissue constituents.

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KW - Broadband

KW - Diffuse Optics

KW - In-vivo

KW - Scattering

KW - Silicon Photomultiplier (SiPM)

KW - Time-Resolved

KW - Turbid media

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AN - SCOPUS:84963948218

SN - 1077-260X

VL - 22

SP - 406

EP - 414

JO - IEEE Journal of Selected Topics in Quantum Electronics

JF - IEEE Journal of Selected Topics in Quantum Electronics

IS - 3

M1 - 7349112

ER -

Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use

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Keywords

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