Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: Characterization and in-vivo measurements in the 600-1350 nm spectral range

  • Sanathana Konugolu Venkata Sekar
  • , Andrea Farina
  • , Edoardo Martinenghi
  • , Alberto Dalla Mora
  • , Paola Taroni
  • , Antonio Pifferi
  • , Turgut Durduran
  • , Marco Pagliazzi
  • , Claus Lindner
  • , Parisa Farzam
  • , Mireia Mora
  • , Mattia Squarcia
  • , A. Urbano-Ispizua

Research output: Chapter in Book/Report/Conference proceedingsChapterpeer-review

Abstract

We report on the design, performance assessment, and first in vivo measurement of a Time-Resolved Diffuse Optical system for broadband (600-1350 nm) nm measurement of absorption and scattering spectra of biological tissues for non-invasive clinical diagnostics. Two strategies to reduce drift and enhance responsivity are adopted. The system was enrolled in a first in vivo test phase on healthy volunteers, carrying out non-invasive, in vivo quantification of key tissue constituents (oxy- and deoxy-hemoglobin, water, lipids, collagen) and tissue micro-structure (scatterer size and density).

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2015
EditorsPaola Taroni, Hamid Dehghani
PublisherSPIE
ISBN (Electronic)9781628417036
ISBN (Print)9781628417012
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventEuropean Conference on Biomedical Optics, ECBO 2015 - Munich, Germany
Duration: 21 Jun 201525 Jun 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9538
ISSN (Print)1605-7422

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO 2015
Country/TerritoryGermany
CityMunich
Period21/06/1525/06/15

Keywords

  • absorption
  • detector
  • in-vivo
  • MEDPHOT protocol
  • scattering
  • silicon photomultiplier (SiPM)
  • time-resolved spectroscopy

Fingerprint

Dive into the research topics of 'Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: Characterization and in-vivo measurements in the 600-1350 nm spectral range'. Together they form a unique fingerprint.

Cite this