Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats

P. L. Janssen; K. D. O'Halloran; J. Pizarro; M. R. Dwinell; G. E. Bisgard

doi:10.1016/S0034-5687(97)00060-1

Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats

P. L. Janssen
, K. D. O'Halloran
, J. Pizarro
, M. R. Dwinell
, G. E. Bisgard

University of Wisconsin-Madison

Research output: Contribution to journal › Article › peer-review

Abstract

Ventilatory acclimatization to sustained hypoxia (VASH) is the time- dependent increase in ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg · kg^-1) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat.

Original language	English
Pages (from-to)	25-32
Number of pages	8
Journal	Respiration Physiology
Volume	111
Issue number	1
DOIs	https://doi.org/10.1016/S0034-5687(97)00060-1
Publication status	Published - Jan 1998
Externally published	Yes

Keywords

Carotid body, sustained hypoxia, dopamine
Control of breathing, sustained hypoxia, carotid body
Hypoxia, sustained, ventilatory acclimation, carotid body
Mammals, goat
Mediators, dopamine
Pharmacological agents, domperidone

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10.1016/S0034-5687(97)00060-1

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title = "Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats",

abstract = "Ventilatory acclimatization to sustained hypoxia (VASH) is the time- dependent increase in ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg · kg-1) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat.",

keywords = "Carotid body, sustained hypoxia, dopamine, Control of breathing, sustained hypoxia, carotid body, Hypoxia, sustained, ventilatory acclimation, carotid body, Mammals, goat, Mediators, dopamine, Pharmacological agents, domperidone",

author = "Janssen, \{P. L.\} and O'Halloran, \{K. D.\} and J. Pizarro and Dwinell, \{M. R.\} and Bisgard, \{G. E.\}",

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doi = "10.1016/S0034-5687(97)00060-1",

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TY - JOUR

T1 - Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats

AU - Janssen, P. L.

AU - O'Halloran, K. D.

AU - Pizarro, J.

AU - Dwinell, M. R.

AU - Bisgard, G. E.

PY - 1998/1

Y1 - 1998/1

N2 - Ventilatory acclimatization to sustained hypoxia (VASH) is the time- dependent increase in ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg · kg-1) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat.

AB - Ventilatory acclimatization to sustained hypoxia (VASH) is the time- dependent increase in ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg · kg-1) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat.

KW - Carotid body, sustained hypoxia, dopamine

KW - Control of breathing, sustained hypoxia, carotid body

KW - Hypoxia, sustained, ventilatory acclimation, carotid body

KW - Mammals, goat

KW - Mediators, dopamine

KW - Pharmacological agents, domperidone

UR - https://www.scopus.com/pages/publications/0031963774

U2 - 10.1016/S0034-5687(97)00060-1

DO - 10.1016/S0034-5687(97)00060-1

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SN - 0034-5687

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IS - 1

ER -

Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats

Abstract

Keywords

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