Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood

Gerard Clarke; Siobhain M. O'Mahony; Alan A. Hennessy; Paul Ross; Catherine Stanton; John F. Cryan; Timothy G. Dinan

doi:10.1016/j.bbr.2009.07.008

Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood

Gerard Clarke
, Siobhain M. O'Mahony
, Alan A. Hennessy
, Paul Ross
, Catherine Stanton
, John F. Cryan
, Timothy G. Dinan

Research output: Contribution to journal › Article › peer-review

Abstract

The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.

Original language	English
Pages (from-to)	319-321
Number of pages	3
Journal	Behavioural Brain Research
Volume	205
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2009.07.008
Publication status	Published - 14 Dec 2009

Keywords

Animal model
Arachidonic acid
Depression
Gas chromatography
Maternal separation
Stress

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10.1016/j.bbr.2009.07.008

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abstract = "The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.",

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AU - Clarke, Gerard

AU - O'Mahony, Siobhain M.

AU - Hennessy, Alan A.

AU - Ross, Paul

AU - Stanton, Catherine

AU - Cryan, John F.

AU - Dinan, Timothy G.

PY - 2009/12/14

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KW - Animal model

KW - Arachidonic acid

KW - Depression

KW - Gas chromatography

KW - Maternal separation

KW - Stress

UR - https://www.scopus.com/pages/publications/70349301361

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DO - 10.1016/j.bbr.2009.07.008

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EP - 321

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood

Abstract

Keywords

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