CHAPTER 3: Evolution of Cell-penetrating Phosphorescent O2 Probes

  • Dmitri B. Papkovsky
  • , Ruslan I. Dmitriev

Research output: Chapter in Book/Report/Conference proceedingsChapterpeer-review

Abstract

Advances in materials science, chemistry, sensor design, bioconjugation and nanotechnology helped to develop a new class of phosphorescent cell-penetrating O2-sensitive materials, enabling non-invasive sensing of intracellular O2 and its gradients in live cells. Cell-penetrating O2 probes compatible with live cell and tissue imaging are available to solve many biomedical problems and complement disease-oriented tissue models. Here, we critically review the evolution of research on cell-penetrating O2 probes and provide their classification based on the chemical structures and material design, highlighting their biomedical applications.

Original languageEnglish
Title of host publicationQuenched-phosphorescence Detection of Molecular Oxygen
Subtitle of host publicationApplications in Life Sciences
EditorsDmitri B. Papkovsky, Ruslan I. Dmitriev
PublisherRoyal Society of Chemistry
Pages50-70
Number of pages21
Edition11
ISBN (Electronic)9781788011754
DOIs
Publication statusPublished - 2018

Publication series

NameRSC Detection Science
Number11
Volume2018-January
ISSN (Print)2052-3068
ISSN (Electronic)2052-3076

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