TY - CHAP
T1 - Characterization and design of 3D scaffolds for biofluidic criteria
AU - Li, Qing
AU - Yu, Jiani
AU - Schellekens, Michiel
AU - Zhou, Shiwei
AU - Li, Wei
AU - Armfield, Steven
AU - Appleyard, Richard
PY - 2009
Y1 - 2009
N2 - The success of tissue regeneration to a certain extent lies on the mechanical and biological environments that the scaffold provides. The former has been addressed in terms of stiffness and strength in a range of tissue engineering scenarios. The latter is often related to fluid flow capacity of facilitating nutrient delivery, waste removal, and more importantly promoting tissue remodeling. This paper aims at developing a computational fluid dynamics (CFD) analysis for scaffold characterization and design in terms of fluidic wall shear stress. A certain level of wall shear stress (WSS) is considered essential to stimulate the cell differentiation and tissue growth, thereby making load-bearing neotissue more functional. This paper will firstly examine the transporting performance of scaffold topology that was designed based upon the stiffness criterion. Then a WSS based topological design is developed by using bidirectional evolutionary structural optimization (BESO) method, where a more uniform and favorable WSS distribution can be obtained.
AB - The success of tissue regeneration to a certain extent lies on the mechanical and biological environments that the scaffold provides. The former has been addressed in terms of stiffness and strength in a range of tissue engineering scenarios. The latter is often related to fluid flow capacity of facilitating nutrient delivery, waste removal, and more importantly promoting tissue remodeling. This paper aims at developing a computational fluid dynamics (CFD) analysis for scaffold characterization and design in terms of fluidic wall shear stress. A certain level of wall shear stress (WSS) is considered essential to stimulate the cell differentiation and tissue growth, thereby making load-bearing neotissue more functional. This paper will firstly examine the transporting performance of scaffold topology that was designed based upon the stiffness criterion. Then a WSS based topological design is developed by using bidirectional evolutionary structural optimization (BESO) method, where a more uniform and favorable WSS distribution can be obtained.
KW - Bioreactor
KW - Computational fluid dynamics
KW - Scaffold
KW - Tissue engineering
KW - Topology optimization
KW - Wall shear stress
UR - https://www.scopus.com/pages/publications/77950798290
U2 - 10.1109/CIMSA.2009.5069957
DO - 10.1109/CIMSA.2009.5069957
M3 - Chapter
AN - SCOPUS:77950798290
SN - 9781424438204
T3 - 2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
SP - 238
EP - 241
BT - 2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
T2 - 2009 IEEE International Conference on Computational Intelligence for Measurement Systems and Applications, CIMSA 2009
Y2 - 11 May 2009 through 13 May 2009
ER -