Characterization of probe contact effects on diffuse reflectance spectroscopy measurements

Research output: Chapter in Book/Report/Conference proceedingsConference proceedingpeer-review

Abstract

Diffuse reflectance spectroscopy (DRS) is a rapid, non-invasive optical method widely adopted to gain diagnostic information of tissue. The most flexible approach to this method is a fiber-optic contact-probe used with a spectroscopy system. A challenge of this method is that the external pressure brought by the probe can significantly affect the tissue optical properties as well as the light coupling into the probe, and thus influence the collected DRS-spectrum. In this study we investigate and characterize the effect of probe pressure on DRS-spectra obtained with a calibrated loaded-spring system used with a fiber optic probe in the range (400 - 1600) nm. A multilayer FE-model of the indentation is developed to get a better insight of the distribution of pressure and stresses inside the skin under indentation.

Original languageEnglish
Title of host publicationBiophotonics South America
EditorsKatarina Svanberg, Cristina Kurachi, Vanderlei Salvador Bagnato, Bruce J. Tromberg
PublisherSPIE
ISBN (Electronic)9781628416961
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventBiophotonics South America - Rio de Janeiro, Brazil
Duration: 23 May 201525 May 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9531
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics South America
Country/TerritoryBrazil
CityRio de Janeiro
Period23/05/1525/05/15

Keywords

  • biomechanical
  • Diffuse reflectance spectroscopy
  • finite element simulation
  • probe contact pressure
  • tissue optical properties

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