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Clinical detection studies of Barrett's metaplasia and oesophageal adenocarcinoma by means of laser-induced fluorescence

  • Annika M. Nilsson
  • , Christer S. Holstein
  • , Stefan Andersson-Engels
  • , Roger Willen
  • , Bruno Walther
  • , Katarina M.D. Svanberg

Research output: Chapter in Book/Report/Conference proceedingsConference proceedingpeer-review

Abstract

Five patients with Barrett's metaplasic epithelium were investigated by means of laser-induced fluorescence after low-dose i.v. injection (0.35 mg/kg b.w.) of Photofrin R in connection with endoscopy procedures. The excitation wavelength was 405 nm. Recorded fluorescence spectra were evaluated by forming ratios with the photosensitizer fluorescence as numerator and the autofluorescence as denominator. Two patients had no evidence of malignancy and their fluorescence ratios were consequently rather small, whereas the other three patients had adenocarcinoma and showed considerably higher ratios. The results indicate that laser-induced fluorescence can be used as an aid in detecting malignant transformations in Barrett's metaplasia.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsRinaldo Cubeddu, Serge R. Mordon, Katarina Svanberg
Pages49-56
Number of pages8
Publication statusPublished - 1995
Externally publishedYes
EventOptical Biopsies - Barcelona, Spain
Duration: 14 Sep 199515 Sep 1995

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2627
ISSN (Print)0277-786X

Conference

ConferenceOptical Biopsies
CityBarcelona, Spain
Period14/09/9515/09/95

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