Colonization of the human gut by bovine bacteria present in Parmesan cheese

Christian Milani; Sabrina Duranti; Stefania Napoli; Giulia Alessandri; Leonardo Mancabelli; Rosaria Anzalone; Giulia Longhi; Alice Viappiani; Marta Mangifesta; Gabriele Andrea Lugli; Sergio Bernasconi; Maria Cristina Ossiprandi; Douwe van Sinderen; Marco Ventura; Francesca Turroni

doi:10.1038/s41467-019-09303-w

Colonization of the human gut by bovine bacteria present in Parmesan cheese

Christian Milani
, Sabrina Duranti
, Stefania Napoli
, Giulia Alessandri
, Leonardo Mancabelli
, Rosaria Anzalone
, Giulia Longhi
, Alice Viappiani
, Marta Mangifesta
, Gabriele Andrea Lugli
, Sergio Bernasconi
, Maria Cristina Ossiprandi
, Douwe van Sinderen
, Marco Ventura
, Francesca Turroni

Research output: Contribution to journal › Article › peer-review

Abstract

The abilities of certain microorganisms to be transferred across the food production chain, persist in the final product and, potentially, colonize the human gut are poorly understood. Here, we provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese. We characterize the microbial communities in samples taken from five different locations across the Parmesan cheese production chain, confirming that the final product contains microorganisms derived from cattle gut, milk, and the nearby environment. In addition, we carry out a human pilot study showing that Bifidobacterium mongoliense strains from cheese can transiently colonize the human gut, a process that can be enhanced by cow milk consumption.

Original language	English
Article number	1286
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-09303-w
Publication status	Published - 1 Dec 2019

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10.1038/s41467-019-09303-w

https://hdl.handle.net/10468/9065Licence: CC BY

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Milani, C., Duranti, S., Napoli, S., Alessandri, G., Mancabelli, L., Anzalone, R., Longhi, G., Viappiani, A., Mangifesta, M., Lugli, G. A., Bernasconi, S., Ossiprandi, M. C., van Sinderen, D., Ventura, M., & Turroni, F. (2019). Colonization of the human gut by bovine bacteria present in Parmesan cheese. Nature Communications, 10(1), Article 1286. https://doi.org/10.1038/s41467-019-09303-w

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title = "Colonization of the human gut by bovine bacteria present in Parmesan cheese",

abstract = "The abilities of certain microorganisms to be transferred across the food production chain, persist in the final product and, potentially, colonize the human gut are poorly understood. Here, we provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese. We characterize the microbial communities in samples taken from five different locations across the Parmesan cheese production chain, confirming that the final product contains microorganisms derived from cattle gut, milk, and the nearby environment. In addition, we carry out a human pilot study showing that Bifidobacterium mongoliense strains from cheese can transiently colonize the human gut, a process that can be enhanced by cow milk consumption.",

author = "Christian Milani and Sabrina Duranti and Stefania Napoli and Giulia Alessandri and Leonardo Mancabelli and Rosaria Anzalone and Giulia Longhi and Alice Viappiani and Marta Mangifesta and Lugli, \{Gabriele Andrea\} and Sergio Bernasconi and Ossiprandi, \{Maria Cristina\} and \{van Sinderen\}, Douwe and Marco Ventura and Francesca Turroni",

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year = "2019",

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doi = "10.1038/s41467-019-09303-w",

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Milani, C, Duranti, S, Napoli, S, Alessandri, G, Mancabelli, L, Anzalone, R, Longhi, G, Viappiani, A, Mangifesta, M, Lugli, GA, Bernasconi, S, Ossiprandi, MC, van Sinderen, D, Ventura, M & Turroni, F 2019, 'Colonization of the human gut by bovine bacteria present in Parmesan cheese', Nature Communications, vol. 10, no. 1, 1286. https://doi.org/10.1038/s41467-019-09303-w

TY - JOUR

T1 - Colonization of the human gut by bovine bacteria present in Parmesan cheese

AU - Milani, Christian

AU - Duranti, Sabrina

AU - Napoli, Stefania

AU - Alessandri, Giulia

AU - Mancabelli, Leonardo

AU - Anzalone, Rosaria

AU - Longhi, Giulia

AU - Viappiani, Alice

AU - Mangifesta, Marta

AU - Lugli, Gabriele Andrea

AU - Bernasconi, Sergio

AU - Ossiprandi, Maria Cristina

AU - van Sinderen, Douwe

AU - Ventura, Marco

AU - Turroni, Francesca

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The abilities of certain microorganisms to be transferred across the food production chain, persist in the final product and, potentially, colonize the human gut are poorly understood. Here, we provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese. We characterize the microbial communities in samples taken from five different locations across the Parmesan cheese production chain, confirming that the final product contains microorganisms derived from cattle gut, milk, and the nearby environment. In addition, we carry out a human pilot study showing that Bifidobacterium mongoliense strains from cheese can transiently colonize the human gut, a process that can be enhanced by cow milk consumption.

AB - The abilities of certain microorganisms to be transferred across the food production chain, persist in the final product and, potentially, colonize the human gut are poorly understood. Here, we provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese. We characterize the microbial communities in samples taken from five different locations across the Parmesan cheese production chain, confirming that the final product contains microorganisms derived from cattle gut, milk, and the nearby environment. In addition, we carry out a human pilot study showing that Bifidobacterium mongoliense strains from cheese can transiently colonize the human gut, a process that can be enhanced by cow milk consumption.

UR - https://www.scopus.com/pages/publications/85063336753

U2 - 10.1038/s41467-019-09303-w

DO - 10.1038/s41467-019-09303-w

M3 - Article

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AN - SCOPUS:85063336753

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1286

ER -

Colonization of the human gut by bovine bacteria present in Parmesan cheese

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