Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Aurelia Santoro; Elisa Pini; Maria Scurti; Giustina Palmas; Agnes Berendsen; Anna Brzozowska; Barbara Pietruszka; Anna Szczecinska; Noël Cano; Nathalie Meunier; C. P.G.M. de Groot; Edith Feskens; Susan Fairweather-Tait; Stefano Salvioli; Miriam Capri; Patrizia Brigidi; Claudio Franceschi; Cristina Fabbri; Claudia Bertarelli; Massimo Izzi; Mario Mazzocchi; Jean Michel Chardigny; Beatrice Morio; Daniele Rossi; Maurizio Notarfonso; Paul W. O'Toole; Kevin Cashman; Simon R. Carding; Claudio Nicoletti; Dirk Jacobs; Maria Xipsiti; Laura Fernandez; Josephine Wills; Xavier Irz; Natalia Kuosmanen; Efstathios S. Gonos; Konstantinos Voutetakis; Michael Salmon; Olivier Toussaint; Bruce W. Traill; Giuseppe Nocella; Barbara Caracciolo; Weili Xu; Ikonen Mikko Ikonen; Tuula Tuure; Robert Brummer; Fawzi Kadi; Sylvie Breton; Marie Triomphe; Guido Magario; Filippo Villani; Annibale Pancrazio; Brigitte Teufner; Josef Stocker; Francisco Javier Echevarría; Jose Ramón Iglesias; František Smrž; Lucie Krejcirova; Efthimia Koytsomitropoulou; Konstantinos Georgakidis; Rezan Yornuk; Cihan Ucar; Ben Van Ommen; Jildau Bouwman; Sebastiano Collino; Clara Jankovics; Adrienn Losó; Willem de Vos; Susana Fuentes; Eric Commelin

doi:10.1016/j.mad.2013.12.001

Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Aurelia Santoro
, Elisa Pini
, Maria Scurti
, Giustina Palmas
, Agnes Berendsen
, Anna Brzozowska
, Barbara Pietruszka
, Anna Szczecinska
, Noël Cano
, Nathalie Meunier
, C. P.G.M. de Groot
, Edith Feskens
, Susan Fairweather-Tait
, Stefano Salvioli
, Miriam Capri
, Patrizia Brigidi
, Claudio Franceschi
, Cristina Fabbri
, Claudia Bertarelli
, Massimo Izzi

Mario Mazzocchi, Jean Michel Chardigny, Beatrice Morio, Daniele Rossi, Maurizio Notarfonso, Paul W. O'Toole, Kevin Cashman, Simon R. Carding, Claudio Nicoletti, Dirk Jacobs, Maria Xipsiti, Laura Fernandez, Josephine Wills, Xavier Irz, Natalia Kuosmanen, Efstathios S. Gonos, Konstantinos Voutetakis, Michael Salmon, Olivier Toussaint, Bruce W. Traill, Giuseppe Nocella, Barbara Caracciolo, Weili Xu, Ikonen Mikko Ikonen, Tuula Tuure, Robert Brummer, Fawzi Kadi, Sylvie Breton, Marie Triomphe, Guido Magario, Filippo Villani, Annibale Pancrazio, Brigitte Teufner, Josef Stocker, Francisco Javier Echevarría, Jose Ramón Iglesias, František Smrž, Lucie Krejcirova, Efthimia Koytsomitropoulou, Konstantinos Georgakidis, Rezan Yornuk, Cihan Ucar, Ben Van Ommen, Jildau Bouwman, Sebastiano Collino, Clara Jankovics, Adrienn Losó, Willem de Vos, Susana Fuentes, Eric Commelin

University of Bologna
Wageningen University & Research
Warsaw University of Life Sciences
Université Clermont Auvergne
CHU de Clermont-Ferrand
University of East Anglia
Institut National de la Recherche Agronomique
Spread EuropeanSafetyGeie
Earley Gate
FoodDrinkEurope
European Food Information Council (EUFIC)
Maa Ja Elintarviketalouden Tutkimuskeskus
ETHNIKO IDRYMA EREVNON
Straticell
University of Reading
Karolinska Institutet
VALIO OY
Örebro University
Lesieur SAS
Villani S.p.A.
Pancrazio SpA
Wiesbauer Gourmet Gastro GmbH
Vidreres Llet
Zeelandia
Mevgal SA
YorukSutUrunleriHayvancilikGida San. Ve Tic. Ltd. Şti.
NederlandseOrganisatieVoorToegepast - TNO
Nestle
Mirelite Mirsa Zartkoruen Mukodo Reszvenytarsasag
EC6 Sarl

Research output: Contribution to journal › Article › peer-review

Abstract

The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

Original language	English
Pages (from-to)	3-13
Number of pages	11
Journal	Mechanisms of Ageing and Development
Volume	136-137
DOIs	https://doi.org/10.1016/j.mad.2013.12.001
Publication status	Published - Mar 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure
SDG 11 Sustainable Cities and Communities

Keywords

Ageing
Elderly-tailored foods
Gut microbiota
Inflammaging
Mediterranean diet

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10.1016/j.mad.2013.12.001

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Santoro, A., Pini, E., Scurti, M., Palmas, G., Berendsen, A., Brzozowska, A., Pietruszka, B., Szczecinska, A., Cano, N., Meunier, N., de Groot, C. P. G. M., Feskens, E., Fairweather-Tait, S., Salvioli, S., Capri, M., Brigidi, P., Franceschi, C., Fabbri, C., Bertarelli, C., ... Commelin, E. (2014). Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design. Mechanisms of Ageing and Development, 136-137, 3-13. https://doi.org/10.1016/j.mad.2013.12.001

@article{7710e8050fa140b58532131eac90190f,

title = "Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design",

abstract = "The development of a chronic, low grade, inflammatory status named {"}inflammaging{"} is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food \& Drink Industries.",

keywords = "Ageing, Elderly-tailored foods, Gut microbiota, Inflammaging, Mediterranean diet",

author = "Aurelia Santoro and Elisa Pini and Maria Scurti and Giustina Palmas and Agnes Berendsen and Anna Brzozowska and Barbara Pietruszka and Anna Szczecinska and No{\"e}l Cano and Nathalie Meunier and \{de Groot\}, \{C. P.G.M.\} and Edith Feskens and Susan Fairweather-Tait and Stefano Salvioli and Miriam Capri and Patrizia Brigidi and Claudio Franceschi and Cristina Fabbri and Claudia Bertarelli and Massimo Izzi and Mario Mazzocchi and Chardigny, \{Jean Michel\} and Beatrice Morio and Daniele Rossi and Maurizio Notarfonso and O'Toole, \{Paul W.\} and Kevin Cashman and Carding, \{Simon R.\} and Claudio Nicoletti and Dirk Jacobs and Maria Xipsiti and Laura Fernandez and Josephine Wills and Xavier Irz and Natalia Kuosmanen and Gonos, \{Efstathios S.\} and Konstantinos Voutetakis and Michael Salmon and Olivier Toussaint and Traill, \{Bruce W.\} and Giuseppe Nocella and Barbara Caracciolo and Weili Xu and \{Mikko Ikonen\}, Ikonen and Tuula Tuure and Robert Brummer and Fawzi Kadi and Sylvie Breton and Marie Triomphe and Guido Magario and Filippo Villani and Annibale Pancrazio and Brigitte Teufner and Josef Stocker and Echevarr{\'i}a, \{Francisco Javier\} and Iglesias, \{Jose Ram{\'o}n\} and Franti{\v s}ek Smr{\v z} and Lucie Krejcirova and Efthimia Koytsomitropoulou and Konstantinos Georgakidis and Rezan Yornuk and Cihan Ucar and \{Van Ommen\}, Ben and Jildau Bouwman and Sebastiano Collino and Clara Jankovics and Adrienn Los{\'o} and \{de Vos\}, Willem and Susana Fuentes and Eric Commelin",

year = "2014",

month = mar,

doi = "10.1016/j.mad.2013.12.001",

language = "English",

volume = "136-137",

pages = "3--13",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

}

Santoro, A, Pini, E, Scurti, M, Palmas, G, Berendsen, A, Brzozowska, A, Pietruszka, B, Szczecinska, A, Cano, N, Meunier, N, de Groot, CPGM, Feskens, E, Fairweather-Tait, S, Salvioli, S, Capri, M, Brigidi, P, Franceschi, C, Fabbri, C, Bertarelli, C, Izzi, M, Mazzocchi, M, Chardigny, JM, Morio, B, Rossi, D, Notarfonso, M, O'Toole, PW, Cashman, K, Carding, SR, Nicoletti, C, Jacobs, D, Xipsiti, M, Fernandez, L, Wills, J, Irz, X, Kuosmanen, N, Gonos, ES, Voutetakis, K, Salmon, M, Toussaint, O, Traill, BW, Nocella, G, Caracciolo, B, Xu, W, Mikko Ikonen, I, Tuure, T, Brummer, R, Kadi, F, Breton, S, Triomphe, M, Magario, G, Villani, F, Pancrazio, A, Teufner, B, Stocker, J, Echevarría, FJ, Iglesias, JR, Smrž, F, Krejcirova, L, Koytsomitropoulou, E, Georgakidis, K, Yornuk, R, Ucar, C, Van Ommen, B, Bouwman, J, Collino, S, Jankovics, C, Losó, A, de Vos, W, Fuentes, S & Commelin, E 2014, 'Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design', Mechanisms of Ageing and Development, vol. 136-137, pp. 3-13. https://doi.org/10.1016/j.mad.2013.12.001

TY - JOUR

T1 - Combating inflammaging through a Mediterranean whole diet approach

T2 - The NU-AGE project's conceptual framework and design

AU - Santoro, Aurelia

AU - Pini, Elisa

AU - Scurti, Maria

AU - Palmas, Giustina

AU - Berendsen, Agnes

AU - Brzozowska, Anna

AU - Pietruszka, Barbara

AU - Szczecinska, Anna

AU - Cano, Noël

AU - Meunier, Nathalie

AU - de Groot, C. P.G.M.

AU - Feskens, Edith

AU - Fairweather-Tait, Susan

AU - Salvioli, Stefano

AU - Capri, Miriam

AU - Brigidi, Patrizia

AU - Franceschi, Claudio

AU - Fabbri, Cristina

AU - Bertarelli, Claudia

AU - Izzi, Massimo

AU - Mazzocchi, Mario

AU - Chardigny, Jean Michel

AU - Morio, Beatrice

AU - Rossi, Daniele

AU - Notarfonso, Maurizio

AU - O'Toole, Paul W.

AU - Cashman, Kevin

AU - Carding, Simon R.

AU - Nicoletti, Claudio

AU - Jacobs, Dirk

AU - Xipsiti, Maria

AU - Fernandez, Laura

AU - Wills, Josephine

AU - Irz, Xavier

AU - Kuosmanen, Natalia

AU - Gonos, Efstathios S.

AU - Voutetakis, Konstantinos

AU - Salmon, Michael

AU - Toussaint, Olivier

AU - Traill, Bruce W.

AU - Nocella, Giuseppe

AU - Caracciolo, Barbara

AU - Xu, Weili

AU - Mikko Ikonen, Ikonen

AU - Tuure, Tuula

AU - Brummer, Robert

AU - Kadi, Fawzi

AU - Breton, Sylvie

AU - Triomphe, Marie

AU - Magario, Guido

AU - Villani, Filippo

AU - Pancrazio, Annibale

AU - Teufner, Brigitte

AU - Stocker, Josef

AU - Echevarría, Francisco Javier

AU - Iglesias, Jose Ramón

AU - Smrž, František

AU - Krejcirova, Lucie

AU - Koytsomitropoulou, Efthimia

AU - Georgakidis, Konstantinos

AU - Yornuk, Rezan

AU - Ucar, Cihan

AU - Van Ommen, Ben

AU - Bouwman, Jildau

AU - Collino, Sebastiano

AU - Jankovics, Clara

AU - Losó, Adrienn

AU - de Vos, Willem

AU - Fuentes, Susana

AU - Commelin, Eric

PY - 2014/3

Y1 - 2014/3

N2 - The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

AB - The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

KW - Ageing

KW - Elderly-tailored foods

KW - Gut microbiota

KW - Inflammaging

KW - Mediterranean diet

UR - https://www.scopus.com/pages/publications/84899939543

U2 - 10.1016/j.mad.2013.12.001

DO - 10.1016/j.mad.2013.12.001

M3 - Article

C2 - 24342354

AN - SCOPUS:84899939543

SN - 0047-6374

VL - 136-137

SP - 3

EP - 13

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -

Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Abstract

UN SDGs

Keywords

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