TY - JOUR
T1 - Current challenges and future perspectives in oral absorption research
T2 - An opinion of the UNGAP network
AU - Vinarov, Zahari
AU - Abrahamsson, Bertil
AU - Artursson, Per
AU - Batchelor, Hannah
AU - Berben, Philippe
AU - Bernkop-Schnürch, Andreas
AU - Butler, James
AU - Ceulemans, Jens
AU - Davies, Nigel
AU - Dupont, Didier
AU - Flaten, Gøril Eide
AU - Fotaki, Nikoletta
AU - Griffin, Brendan T.
AU - Jannin, Vincent
AU - Keemink, Janneke
AU - Kesisoglou, Filippos
AU - Koziolek, Mirko
AU - Kuentz, Martin
AU - Mackie, Alan
AU - Meléndez-Martínez, Antonio J.
AU - McAllister, Mark
AU - Müllertz, Anette
AU - O'Driscoll, Caitriona M.
AU - Parrott, Neil
AU - Paszkowska, Jadwiga
AU - Pavek, Petr
AU - Porter, Christopher J.H.
AU - Reppas, Christos
AU - Stillhart, Cordula
AU - Sugano, Kiyohiko
AU - Toader, Elena
AU - Valentová, Kateřina
AU - Vertzoni, Maria
AU - De Wildt, Saskia N.
AU - Wilson, Clive G.
AU - Augustijns, Patrick
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/4
Y1 - 2021/4
N2 - Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
AB - Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
KW - Advanced formulations
KW - Amorphous solid dispersions
KW - Food-drug interactions
KW - In vitro tools
KW - Lipid-based formulations
KW - Microbiome
KW - PBPK modeling
KW - Regional differences
KW - Specific patient populations
UR - https://www.scopus.com/pages/publications/85101727356
U2 - 10.1016/j.addr.2021.02.001
DO - 10.1016/j.addr.2021.02.001
M3 - Review article
C2 - 33610694
AN - SCOPUS:85101727356
SN - 0169-409X
VL - 171
SP - 289
EP - 331
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -