Current clinical trials on the use of light-emitting diode as treatment

Light-emitting diode (LED) has been the focus of medical research due to its unique and promising properties in the treatment of various diseases as buccal diseases (peritonitis, infections, or halitosis), dry eye, neonatal jaundice, fibromyalgia, or chronic obstructive pulmonary disease. This chapter reviews the latest clinical trials on the use of LED lights for the treatment of various diseases. The biggest evidence was found in the treatment of hyperbilirubinemia, where LED therapy is compared with other types of light treatment, reducing the need for exchange transfusion and the possible oxidative stress that conventional phototherapy can cause. However, the results of periodontal therapy with LED lights vary between trials, so standardised protocols are needed to make conclusive recommendations. LED light therapy also appears to be beneficial in the treatment of fibromyalgia and oral infections by reducing pain and certain pathogens, respectively. Finally, LED therapies have also been studied for the treatment of disorders and diseases such as COPD, dry eye, or halitosis. However, more evidence is needed to assess efficacy and safety compared to other treatments. Although more research is needed, the findings of these studies suggest that LED light has great potential as a non-invasive and safe therapeutic option in various medical fields.