Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function.

Collins NT; Cummins PM; Colgan OC; G Ferguson; Birney YA; Murphy RP; G Meade; Cahill PA

doi:10.1161/01.atv.0000194097.92824.b3

Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function.

Collins NT
, Cummins PM
, Colgan OC
, G Ferguson
, Birney YA
, Murphy RP
, G Meade
, Cahill PA

Royal College of Surgeons in Ireland

Research output: Contribution to journal › Article › peer-review

Abstract

The objective of this study was to investigate the effects of cyclic strain on the expression, modification, and function of 2 pivotal endothelial tight junction components: occludin and ZO-1. Our findings indicate that cyclic strain modulates the expression and phosphorylation of both proteins with consequences for their association and subcellular localization at the cell-cell border and, ultimately, for endothelial barrier integrity.

Original language	English
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
DOIs	https://doi.org/10.1161/01.atv.0000194097.92824.b3
Publication status	Published - Nov 2005
Externally published	Yes

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title = "Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function.",

abstract = "The objective of this study was to investigate the effects of cyclic strain on the expression, modification, and function of 2 pivotal endothelial tight junction components: occludin and ZO-1. Our findings indicate that cyclic strain modulates the expression and phosphorylation of both proteins with consequences for their association and subcellular localization at the cell-cell border and, ultimately, for endothelial barrier integrity.",

author = "Collins NT and Cummins PM and Colgan OC and G Ferguson and Birney YA and Murphy RP and G Meade and Cahill PA",

year = "2005",

month = nov,

doi = "10.1161/01.atv.0000194097.92824.b3",

language = "English",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

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AU - PM, Cummins

AU - OC, Colgan

AU - Ferguson, G

AU - YA, Birney

AU - RP, Murphy

AU - Meade, G

AU - PA, Cahill

PY - 2005/11

Y1 - 2005/11

N2 - The objective of this study was to investigate the effects of cyclic strain on the expression, modification, and function of 2 pivotal endothelial tight junction components: occludin and ZO-1. Our findings indicate that cyclic strain modulates the expression and phosphorylation of both proteins with consequences for their association and subcellular localization at the cell-cell border and, ultimately, for endothelial barrier integrity.

AB - The objective of this study was to investigate the effects of cyclic strain on the expression, modification, and function of 2 pivotal endothelial tight junction components: occludin and ZO-1. Our findings indicate that cyclic strain modulates the expression and phosphorylation of both proteins with consequences for their association and subcellular localization at the cell-cell border and, ultimately, for endothelial barrier integrity.

UR - http://europepmc.org/abstract/med/16269664

U2 - 10.1161/01.atv.0000194097.92824.b3

DO - 10.1161/01.atv.0000194097.92824.b3

M3 - Article

C2 - 16269664

SN - 1079-5642

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

ER -

Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function.

Abstract

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