Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR

Bernard Degryse; Mishan Britto; Chun Xu Shan; Robert G Wallace; Keith D Rochfort; Philip M Cummins; Gerardene Meade; Ronan P Murphy

doi:10.1016/j.dib.2017.10.023

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR

Bernard Degryse
, Mishan Britto
, Chun Xu Shan
, Robert G Wallace
, Keith D Rochfort
, Philip M Cummins
, Gerardene Meade
, Ronan P Murphy

School of Medicine

Dublin City University

Research output: Contribution to journal › Article › peer-review

Abstract

The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively.

Original language	English
Pages (from-to)	600-605
Number of pages	6
Journal	Data in Brief
Volume	15
DOIs	https://doi.org/10.1016/j.dib.2017.10.023
Publication status	Published - Dec 2017

Access to Document

10.1016/j.dib.2017.10.023

Cite this

@article{4af03128f88349f898f97fe4533b6991,

title = "Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR",

abstract = "The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively.",

author = "Bernard Degryse and Mishan Britto and Shan, \{Chun Xu\} and Wallace, \{Robert G\} and Rochfort, \{Keith D\} and Cummins, \{Philip M\} and Gerardene Meade and Murphy, \{Ronan P\}",

year = "2017",

month = dec,

doi = "10.1016/j.dib.2017.10.023",

language = "English",

volume = "15",

pages = "600--605",

journal = "Data in Brief",

issn = "2352-3409",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Data on the regulation of moesin and merlin by the urokinase receptor (uPAR)

T2 - Model explaining distal activation of integrins by uPAR

AU - Degryse, Bernard

AU - Britto, Mishan

AU - Shan, Chun Xu

AU - Wallace, Robert G

AU - Rochfort, Keith D

AU - Cummins, Philip M

AU - Meade, Gerardene

AU - Murphy, Ronan P

PY - 2017/12

Y1 - 2017/12

N2 - The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively.

AB - The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively.

UR - http://europepmc.org/abstract/med/29085875

U2 - 10.1016/j.dib.2017.10.023

DO - 10.1016/j.dib.2017.10.023

M3 - Article

C2 - 29085875

SN - 2352-3409

VL - 15

SP - 600

EP - 605

JO - Data in Brief

JF - Data in Brief

ER -

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR

Abstract

Access to Document

Other files and links

Fingerprint

Cite this