TY - JOUR
T1 - Development of a functional dairy snack containing oleoylethanolamide that reduces food intake in normal-weight and obese minipigs
AU - Boudry, Gaëlle
AU - Mennella, Ilario
AU - Menard, Olivia
AU - Janvier, Régis
AU - Nogret, Isabelle
AU - Madadlou, Ashkan
AU - Cahu, Armelle
AU - Le Normand, Laurence
AU - Bobillier-Chaumont, Eric
AU - Ferracane, Rosalia
AU - Vitaglione, Paola
AU - Dupont, Didier
AU - Val-Laillet, David
N1 - Publisher Copyright:
© 2023
PY - 2023/12
Y1 - 2023/12
N2 - Oleoylethanolamide (OEA) is a safe bioactive lipid that demonstrated strong anorexigenic properties in preclinical and clinical models. In order to evaluate the importance of OEA delivery kinetic on its anorectic properties, we developed OEA-containing dairy snacks with either a liquid or a semi-solid form. The OEA+ liquid snack, but not the semi-solid one, reduced by 14 and 18 % the amount of feed eaten by normal-weight and obese minipigs, respectively, in an eating behavior test performed 4 h after snack ingestion. In vitro digestion experiments revealed that OEA release in intestinal digesta was greatly enhanced when the snack was liquid compared to the semi-solid structure. Kinetic investigations of several plasma parameters after liquid snack ingestion points towards different potential mechanism depending upon the minipig weight status, with an effect of the OEA+ liquid snack likely on endocannabinoid and other related N-acylethanolamine metabolism in normal-weight minipigs and on ketogenesis in obese ones.
AB - Oleoylethanolamide (OEA) is a safe bioactive lipid that demonstrated strong anorexigenic properties in preclinical and clinical models. In order to evaluate the importance of OEA delivery kinetic on its anorectic properties, we developed OEA-containing dairy snacks with either a liquid or a semi-solid form. The OEA+ liquid snack, but not the semi-solid one, reduced by 14 and 18 % the amount of feed eaten by normal-weight and obese minipigs, respectively, in an eating behavior test performed 4 h after snack ingestion. In vitro digestion experiments revealed that OEA release in intestinal digesta was greatly enhanced when the snack was liquid compared to the semi-solid structure. Kinetic investigations of several plasma parameters after liquid snack ingestion points towards different potential mechanism depending upon the minipig weight status, with an effect of the OEA+ liquid snack likely on endocannabinoid and other related N-acylethanolamine metabolism in normal-weight minipigs and on ketogenesis in obese ones.
KW - Food structure
KW - In vitro digestion
KW - N-acylethanolamine
KW - Regulation of food intake
UR - https://www.scopus.com/pages/publications/85177813725
U2 - 10.1016/j.jff.2023.105916
DO - 10.1016/j.jff.2023.105916
M3 - Article
AN - SCOPUS:85177813725
SN - 1756-4646
VL - 111
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 105916
ER -