Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water

Shifa Felemban; Patricia Vazquez; Jan Dehnert; Vadim Goridko; Maria Tijero; Eric Moore

doi:10.1117/12.2265011

Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water

Shifa Felemban
, Patricia Vazquez
, Jan Dehnert
, Vadim Goridko
, Maria Tijero
, Eric Moore

School of Chemistry

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

The work described in this manuscript focuses on how the integration of immunoassay techniques in combination with electrochemical detection can provide a portable and very accurate solution for detection of water pollutants that are detrimental for human health. In particular, we focus our work on the quantification of polycyclic aromatic hydrocarbons (PAHs) in polluted water. Our integrative approach facilitates a real-time detection of this family of organic compounds, by reducing the time of analysis to less than one hour. Additionally, the use of a lab-on-a-chip platform delivers a portable solution that could be used in situ. Optimization of a displacement assay that investigates the presence and concentration of Benzo[a]pyrene in water, allows with the miniaturization of the standard ELISA format into a highly accurate system that provides fast results. The limits of detection obtained are comparable to those of available state-of-the art tools, and achieve the values set by European Drinking Water Directive, 0.10ng/l, as the limit for PAHs in drinking water.

Original language	English
Title of host publication	Smart Sensors, Actuators, and MEMS VIII
Editors	Mika Prunnila, Luis Fonseca, Erwin Peiner
Publisher	SPIE
ISBN (Electronic)	9781510609938
DOIs	https://doi.org/10.1117/12.2265011
Publication status	Published - 2017
Event	Smart Sensors, Actuators, and MEMS VIII Conference 2017 - Barcelona, Spain Duration: 8 May 2017 → 10 May 2017

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10246
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Smart Sensors, Actuators, and MEMS VIII Conference 2017
Country/Territory	Spain
City	Barcelona
Period	8/05/17 → 10/05/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 6 Clean Water and Sanitation

Keywords

Benzo(a)pyrene
environmental monitoring
lab-on-a-chip electrochemical immunosensor
Polycyclic aromatic hydrocarbons (PAHs)

Access to Document

10.1117/12.2265011

Cite this

Felemban, S., Vazquez, P., Dehnert, J., Goridko, V., Tijero, M., & Moore, E. (2017). Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water. In M. Prunnila, L. Fonseca, & E. Peiner (Eds.), Smart Sensors, Actuators, and MEMS VIII Article 102460B (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10246). SPIE. https://doi.org/10.1117/12.2265011

Felemban, Shifa ; Vazquez, Patricia ; Dehnert, Jan et al. / Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water. Smart Sensors, Actuators, and MEMS VIII. editor / Mika Prunnila ; Luis Fonseca ; Erwin Peiner. SPIE, 2017. (Proceedings of SPIE - The International Society for Optical Engineering).

@inproceedings{929999bef79e4152b3ef0937b424cf42,

title = "Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water",

abstract = "The work described in this manuscript focuses on how the integration of immunoassay techniques in combination with electrochemical detection can provide a portable and very accurate solution for detection of water pollutants that are detrimental for human health. In particular, we focus our work on the quantification of polycyclic aromatic hydrocarbons (PAHs) in polluted water. Our integrative approach facilitates a real-time detection of this family of organic compounds, by reducing the time of analysis to less than one hour. Additionally, the use of a lab-on-a-chip platform delivers a portable solution that could be used in situ. Optimization of a displacement assay that investigates the presence and concentration of Benzo[a]pyrene in water, allows with the miniaturization of the standard ELISA format into a highly accurate system that provides fast results. The limits of detection obtained are comparable to those of available state-of-the art tools, and achieve the values set by European Drinking Water Directive, 0.10ng/l, as the limit for PAHs in drinking water.",

keywords = "Benzo(a)pyrene, environmental monitoring, lab-on-a-chip electrochemical immunosensor, Polycyclic aromatic hydrocarbons (PAHs)",

author = "Shifa Felemban and Patricia Vazquez and Jan Dehnert and Vadim Goridko and Maria Tijero and Eric Moore",

note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; Smart Sensors, Actuators, and MEMS VIII Conference 2017 ; Conference date: 08-05-2017 Through 10-05-2017",

year = "2017",

doi = "10.1117/12.2265011",

language = "English",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

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Felemban, S, Vazquez, P, Dehnert, J, Goridko, V, Tijero, M & Moore, E 2017, Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water. in M Prunnila, L Fonseca & E Peiner (eds), Smart Sensors, Actuators, and MEMS VIII., 102460B, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10246, SPIE, Smart Sensors, Actuators, and MEMS VIII Conference 2017, Barcelona, Spain, 8/05/17. https://doi.org/10.1117/12.2265011

Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water. / Felemban, Shifa; Vazquez, Patricia; Dehnert, Jan et al.
Smart Sensors, Actuators, and MEMS VIII. ed. / Mika Prunnila; Luis Fonseca; Erwin Peiner. SPIE, 2017. 102460B (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10246).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

TY - GEN

T1 - Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water

AU - Felemban, Shifa

AU - Vazquez, Patricia

AU - Dehnert, Jan

AU - Goridko, Vadim

AU - Tijero, Maria

AU - Moore, Eric

PY - 2017

Y1 - 2017

N2 - The work described in this manuscript focuses on how the integration of immunoassay techniques in combination with electrochemical detection can provide a portable and very accurate solution for detection of water pollutants that are detrimental for human health. In particular, we focus our work on the quantification of polycyclic aromatic hydrocarbons (PAHs) in polluted water. Our integrative approach facilitates a real-time detection of this family of organic compounds, by reducing the time of analysis to less than one hour. Additionally, the use of a lab-on-a-chip platform delivers a portable solution that could be used in situ. Optimization of a displacement assay that investigates the presence and concentration of Benzo[a]pyrene in water, allows with the miniaturization of the standard ELISA format into a highly accurate system that provides fast results. The limits of detection obtained are comparable to those of available state-of-the art tools, and achieve the values set by European Drinking Water Directive, 0.10ng/l, as the limit for PAHs in drinking water.

AB - The work described in this manuscript focuses on how the integration of immunoassay techniques in combination with electrochemical detection can provide a portable and very accurate solution for detection of water pollutants that are detrimental for human health. In particular, we focus our work on the quantification of polycyclic aromatic hydrocarbons (PAHs) in polluted water. Our integrative approach facilitates a real-time detection of this family of organic compounds, by reducing the time of analysis to less than one hour. Additionally, the use of a lab-on-a-chip platform delivers a portable solution that could be used in situ. Optimization of a displacement assay that investigates the presence and concentration of Benzo[a]pyrene in water, allows with the miniaturization of the standard ELISA format into a highly accurate system that provides fast results. The limits of detection obtained are comparable to those of available state-of-the art tools, and achieve the values set by European Drinking Water Directive, 0.10ng/l, as the limit for PAHs in drinking water.

KW - Benzo(a)pyrene

KW - environmental monitoring

KW - lab-on-a-chip electrochemical immunosensor

KW - Polycyclic aromatic hydrocarbons (PAHs)

UR - https://www.scopus.com/pages/publications/85025807331

U2 - 10.1117/12.2265011

DO - 10.1117/12.2265011

M3 - Conference proceeding

AN - SCOPUS:85025807331

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Smart Sensors, Actuators, and MEMS VIII

A2 - Prunnila, Mika

A2 - Fonseca, Luis

A2 - Peiner, Erwin

PB - SPIE

T2 - Smart Sensors, Actuators, and MEMS VIII Conference 2017

Y2 - 8 May 2017 through 10 May 2017

ER -

Felemban S, Vazquez P, Dehnert J, Goridko V, Tijero M, Moore E. Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water. In Prunnila M, Fonseca L, Peiner E, editors, Smart Sensors, Actuators, and MEMS VIII. SPIE. 2017. 102460B. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.2265011

Development of a lab-on-chip electrochemical immunosensor for detection of Polycyclic Aromatic Hydrocarbons (PAH) in environmental water

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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