Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Dieter Verzele; Frédéric Lynen; Mike De Vrieze; Adrian G. Wright; Melissa Hanna-Brown; Pat Sandra

doi:10.1039/c2cc16872c

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Dieter Verzele
, Frédéric Lynen
, Mike De Vrieze
, Adrian G. Wright
, Melissa Hanna-Brown
, Pat Sandra

Research output: Contribution to journal › Article › peer-review

Abstract

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood–brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.

Original language	English
Pages (from-to)	1162-1164
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	8
DOIs	https://doi.org/10.1039/c2cc16872c
Publication status	Published - 4 Jan 2012
Externally published	Yes

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10.1039/c2cc16872c

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title = "Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography",

abstract = "A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood–brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.",

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AU - Verzele, Dieter

AU - Lynen, Frédéric

AU - De Vrieze, Mike

AU - Wright, Adrian G.

AU - Hanna-Brown, Melissa

AU - Sandra, Pat

PY - 2012/1/4

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AB - A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood–brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.

UR - https://www.scopus.com/pages/publications/84855594178

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DO - 10.1039/c2cc16872c

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JO - Chemical Communications

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Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Abstract

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