@inproceedings{f1fabb75cdfc4a319e328e39a0d82f70,
title = "Diffuse fluorescence tomography for photodynamic therapy of tumors",
abstract = "We develop and validate diffuse optical tomography methods based on interstitial fluorescence measurements for the reconstruction of fluorescent photosensitizing drug spatial distribution. We propose another phase in the tomographic reconstruction algorithm resulting in quantitatively more accurate reconstruction. This quantitative information can be used to monitor the temporal evolution of the photosensitizing drug concentration in tumor tissue with a final goal to predict the photodynamic treatment outcome and adjust the light dose in real time during the treatment. Capabilities and limitations of the developed reconstruction methods are analyzed in numerical simulations. Experimental validation is conducted on prostate tissue-mimicking phantoms with inclusions containing photosensitizer verteporfin, using a laser light delivery and collection system designed for clinical use.",
keywords = "Diffuse optical tomography, Fluorescence, Hybrid phantoms, Inverse problem, Photodynamic therapy, Photosensitizing drug, Reconstruction",
author = "Stefan {\v S}u{\v s}njar and \{Daniyal Ghauri\}, M. and Bj{\"o}rn Thomasson and Sekar, \{Sanathana Konugolu Venkata\} and Stefan Andersson-Engels and Johannes Swartling and Nina Reistad",
note = "Publisher Copyright: {\textcopyright} 2025 SPIE.; Biomedical Light Scattering XV 2025 ; Conference date: 25-01-2025 Through 26-01-2025",
year = "2025",
doi = "10.1117/12.3041146",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Adam Wax and Vadim Backman",
booktitle = "Biomedical Light Scattering XV",
address = "United States",
}