Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand

JoséM M. Palacios; Christian Waeber; Anne T. Bruinvels; Daniel Hoyer

doi:10.1016/0169-328X(92)90060-O

Direct visualization of serotonin_1D receptors in the human brain using a new iodinated radioligand

JoséM M. Palacios
, Christian Waeber
, Anne T. Bruinvels
, Daniel Hoyer

Novartis

Research output: Contribution to journal › Article › peer-review

Abstract

The development of the new ligand serotonin-5-O-carboxymethyl-glycyl [¹²⁵I]tyrosinamide (abbreviated [¹²⁵I]GTI) allows for the direct visualization of serotonin_1B and serotonin_1D (5-HT_1B/1D) sites. Autoradiographic techniques were used to demonstrate the selective binding of this ligand to 5-HT_1D sites in human post-mortem brain materials. The distribution of [¹²⁵I]GTI binding sites was compared to [³H]5-HT sites in the presence of different displacers. The results show the selective binding of [¹²⁵I]GTI to sites in the basal ganglia and substantia nigra which corresponds to 5-HT_1D receptors.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Molecular Brain Research
Volume	13
Issue number	1-2
DOIs	https://doi.org/10.1016/0169-328X(92)90060-O
Publication status	Published - Mar 1992
Externally published	Yes

Keywords

Globus pallidus
Serotonin-5-O-carboxymethyl-glycyl[I]tyrosinamide
Substantia nigra
[H]Serotonin binding site

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10.1016/0169-328X(92)90060-O

Cite this

@article{e74a150d2f48409b8eb1bb5ac8820876,

title = "Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand",

abstract = "The development of the new ligand serotonin-5-O-carboxymethyl-glycyl [125I]tyrosinamide (abbreviated [125I]GTI) allows for the direct visualization of serotonin1B and serotonin1D (5-HT1B/1D) sites. Autoradiographic techniques were used to demonstrate the selective binding of this ligand to 5-HT1D sites in human post-mortem brain materials. The distribution of [125I]GTI binding sites was compared to [3H]5-HT sites in the presence of different displacers. The results show the selective binding of [125I]GTI to sites in the basal ganglia and substantia nigra which corresponds to 5-HT1D receptors.",

keywords = "Globus pallidus, Serotonin-5-O-carboxymethyl-glycyl[I]tyrosinamide, Substantia nigra, [H]Serotonin binding site",

author = "Palacios, \{Jos{\'e}M M.\} and Christian Waeber and Bruinvels, \{Anne T.\} and Daniel Hoyer",

year = "1992",

month = mar,

doi = "10.1016/0169-328X(92)90060-O",

language = "English",

volume = "13",

pages = "175--178",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand

AU - Palacios, JoséM M.

AU - Waeber, Christian

AU - Bruinvels, Anne T.

AU - Hoyer, Daniel

PY - 1992/3

Y1 - 1992/3

N2 - The development of the new ligand serotonin-5-O-carboxymethyl-glycyl [125I]tyrosinamide (abbreviated [125I]GTI) allows for the direct visualization of serotonin1B and serotonin1D (5-HT1B/1D) sites. Autoradiographic techniques were used to demonstrate the selective binding of this ligand to 5-HT1D sites in human post-mortem brain materials. The distribution of [125I]GTI binding sites was compared to [3H]5-HT sites in the presence of different displacers. The results show the selective binding of [125I]GTI to sites in the basal ganglia and substantia nigra which corresponds to 5-HT1D receptors.

AB - The development of the new ligand serotonin-5-O-carboxymethyl-glycyl [125I]tyrosinamide (abbreviated [125I]GTI) allows for the direct visualization of serotonin1B and serotonin1D (5-HT1B/1D) sites. Autoradiographic techniques were used to demonstrate the selective binding of this ligand to 5-HT1D sites in human post-mortem brain materials. The distribution of [125I]GTI binding sites was compared to [3H]5-HT sites in the presence of different displacers. The results show the selective binding of [125I]GTI to sites in the basal ganglia and substantia nigra which corresponds to 5-HT1D receptors.

KW - Globus pallidus

KW - Serotonin-5-O-carboxymethyl-glycyl[I]tyrosinamide

KW - Substantia nigra

KW - [H]Serotonin binding site

UR - https://www.scopus.com/pages/publications/0026514112

U2 - 10.1016/0169-328X(92)90060-O

DO - 10.1016/0169-328X(92)90060-O

M3 - Article

C2 - 1315914

AN - SCOPUS:0026514112

SN - 0169-328X

VL - 13

SP - 175

EP - 178

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

Direct visualization of serotonin_1D receptors in the human brain using a new iodinated radioligand

Abstract

Keywords

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