Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus

Padraig Mcgettrick; Willard Tinago; Julie O'brien; Sarah Miles; Leo Lawler; Alejandro Garcia-Leon; Niall Mahon; John Lambert; Gerard Sheehan; Alan Landay; Caroline A. Sabin; Aoife G. Cotter; Patrick W.G. Mallon; P. Mcgettrick; E. Alvarez Barco; W. Tinago; A. Garcia-Leon; A. Mcdermott; T. Mcginty; A. G. Cotter; A. Macken; P. W.G. Mallon; E. Kavanagh; G. Mccarthy; G. Sheehan; J. Lambert; W. Powderly; J. Compston; C. Sabin; A. Cotter; E. Muldoon; G. Sheehan; T. Mcginty; J. S. Lambert; S. Green; K. Leamy; G. Kenny; K. Mccann; R. Mccann; C. O'broin; S. Waqas; S. Savinelli; E. Feeney; P. W.G. Mallon; A. Garcia Leon; S. Miles; D. Alalwan; R. Negi; E. De Barra; S. Mcconkey; K. Hurley; I. Sulaiman; M. Horgan; C. Sadlier; J. Eustace; C. Kelly; T. Bracken; B. Whelan; J. Low; O. Yousif; B. Mcnicholas; G. Courtney; P. Gavin

doi:10.1093/infdis/jiae007

Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus

Padraig Mcgettrick
, Willard Tinago
, Julie O'brien
, Sarah Miles
, Leo Lawler
, Alejandro Garcia-Leon
, Niall Mahon
, John Lambert
, Gerard Sheehan
, Alan Landay
, Caroline A. Sabin
, Aoife G. Cotter
, Patrick W.G. Mallon
, P. Mcgettrick
, E. Alvarez Barco
, W. Tinago
, A. Garcia-Leon
, A. Mcdermott
, T. Mcginty
, A. G. Cotter

A. Macken, P. W.G. Mallon, E. Kavanagh, G. Mccarthy, G. Sheehan, J. Lambert, W. Powderly, J. Compston, C. Sabin, A. Cotter, E. Muldoon, G. Sheehan, T. Mcginty, J. S. Lambert, S. Green, K. Leamy, G. Kenny, K. Mccann, R. Mccann, C. O'broin, S. Waqas, S. Savinelli, E. Feeney, P. W.G. Mallon, A. Garcia Leon, S. Miles, D. Alalwan, R. Negi, E. De Barra, S. Mcconkey, K. Hurley, I. Sulaiman, M. Horgan, C. Sadlier, J. Eustace, C. Kelly, T. Bracken, B. Whelan, J. Low, O. Yousif, B. Mcnicholas, G. Courtney, P. Gavin

School of Medicine

University College Dublin
Mid-Western Regional Maternity Hospital
Rush University Medical Center
University College London

Research output: Contribution to journal › Article › peer-review

Abstract

Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.

Original language	English
Pages (from-to)	e616-e621
Journal	Journal of Infectious Diseases
Volume	230
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiae007
Publication status	Published - 15 Sep 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CVD
HIV
inflammation
Inflammatory phenotypes
subclinical CAD

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10.1093/infdis/jiae007

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Mcgettrick, P., Tinago, W., O'brien, J., Miles, S., Lawler, L., Garcia-Leon, A., Mahon, N., Lambert, J., Sheehan, G., Landay, A., Sabin, C. A., Cotter, A. G., Mallon, P. W. G., Mcgettrick, P., Alvarez Barco, E., Tinago, W., Garcia-Leon, A., Mcdermott, A., Mcginty, T., ... Gavin, P. (2024). Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus. Journal of Infectious Diseases, 230(3), e616-e621. https://doi.org/10.1093/infdis/jiae007

@article{44664e91811848978ada7968c5996012,

title = "Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus",

abstract = "Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.",

keywords = "CVD, HIV, inflammation, Inflammatory phenotypes, subclinical CAD",

author = "Padraig Mcgettrick and Willard Tinago and Julie O'brien and Sarah Miles and Leo Lawler and Alejandro Garcia-Leon and Niall Mahon and John Lambert and Gerard Sheehan and Alan Landay and Sabin, \{Caroline A.\} and Cotter, \{Aoife G.\} and Mallon, \{Patrick W.G.\} and P. Mcgettrick and \{Alvarez Barco\}, E. and W. Tinago and A. Garcia-Leon and A. Mcdermott and T. Mcginty and Cotter, \{A. G.\} and A. Macken and Mallon, \{P. W.G.\} and E. Kavanagh and G. Mccarthy and G. Sheehan and J. Lambert and W. Powderly and J. Compston and C. Sabin and A. Cotter and E. Muldoon and G. Sheehan and T. Mcginty and Lambert, \{J. S.\} and S. Green and K. Leamy and G. Kenny and K. Mccann and R. Mccann and C. O'broin and S. Waqas and S. Savinelli and E. Feeney and Mallon, \{P. W.G.\} and \{Garcia Leon\}, A. and S. Miles and D. Alalwan and R. Negi and \{De Barra\}, E. and S. Mcconkey and K. Hurley and I. Sulaiman and M. Horgan and C. Sadlier and J. Eustace and C. Kelly and T. Bracken and B. Whelan and J. Low and O. Yousif and B. Mcnicholas and G. Courtney and P. Gavin",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",

year = "2024",

month = sep,

day = "15",

doi = "10.1093/infdis/jiae007",

language = "English",

volume = "230",

pages = "e616--e621",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

Mcgettrick, P, Tinago, W, O'brien, J, Miles, S, Lawler, L, Garcia-Leon, A, Mahon, N, Lambert, J, Sheehan, G, Landay, A, Sabin, CA, Cotter, AG, Mallon, PWG, Mcgettrick, P, Alvarez Barco, E, Tinago, W, Garcia-Leon, A, Mcdermott, A, Mcginty, T, Cotter, AG, Macken, A, Mallon, PWG, Kavanagh, E, Mccarthy, G, Sheehan, G, Lambert, J, Powderly, W, Compston, J, Sabin, C, Cotter, A, Muldoon, E, Sheehan, G, Mcginty, T, Lambert, JS, Green, S, Leamy, K, Kenny, G, Mccann, K, Mccann, R, O'broin, C, Waqas, S, Savinelli, S, Feeney, E, Mallon, PWG, Garcia Leon, A, Miles, S, Alalwan, D, Negi, R, De Barra, E, Mcconkey, S, Hurley, K, Sulaiman, I, Horgan, M, Sadlier, C, Eustace, J, Kelly, C, Bracken, T, Whelan, B, Low, J, Yousif, O, Mcnicholas, B, Courtney, G & Gavin, P 2024, 'Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus', Journal of Infectious Diseases, vol. 230, no. 3, pp. e616-e621. https://doi.org/10.1093/infdis/jiae007

TY - JOUR

T1 - Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus

AU - Mcgettrick, Padraig

AU - Tinago, Willard

AU - O'brien, Julie

AU - Miles, Sarah

AU - Lawler, Leo

AU - Garcia-Leon, Alejandro

AU - Mahon, Niall

AU - Lambert, John

AU - Sheehan, Gerard

AU - Landay, Alan

AU - Sabin, Caroline A.

AU - Cotter, Aoife G.

AU - Mallon, Patrick W.G.

AU - Mcgettrick, P.

AU - Alvarez Barco, E.

AU - Tinago, W.

AU - Garcia-Leon, A.

AU - Mcdermott, A.

AU - Mcginty, T.

AU - Cotter, A. G.

AU - Macken, A.

AU - Mallon, P. W.G.

AU - Kavanagh, E.

AU - Mccarthy, G.

AU - Sheehan, G.

AU - Lambert, J.

AU - Powderly, W.

AU - Compston, J.

AU - Sabin, C.

AU - Cotter, A.

AU - Muldoon, E.

AU - Sheehan, G.

AU - Mcginty, T.

AU - Lambert, J. S.

AU - Green, S.

AU - Leamy, K.

AU - Kenny, G.

AU - Mccann, K.

AU - Mccann, R.

AU - O'broin, C.

AU - Waqas, S.

AU - Savinelli, S.

AU - Feeney, E.

AU - Mallon, P. W.G.

AU - Garcia Leon, A.

AU - Miles, S.

AU - Alalwan, D.

AU - Negi, R.

AU - De Barra, E.

AU - Mcconkey, S.

AU - Hurley, K.

AU - Sulaiman, I.

AU - Horgan, M.

AU - Sadlier, C.

AU - Eustace, J.

AU - Kelly, C.

AU - Bracken, T.

AU - Whelan, B.

AU - Low, J.

AU - Yousif, O.

AU - Mcnicholas, B.

AU - Courtney, G.

AU - Gavin, P.

PY - 2024/9/15

Y1 - 2024/9/15

N2 - Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.

AB - Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.

KW - CVD

KW - HIV

KW - inflammation

KW - Inflammatory phenotypes

KW - subclinical CAD

UR - https://www.scopus.com/pages/publications/85187307608

U2 - 10.1093/infdis/jiae007

DO - 10.1093/infdis/jiae007

M3 - Article

C2 - 38214571

AN - SCOPUS:85187307608

SN - 0022-1899

VL - 230

SP - e616-e621

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus

Abstract

UN SDGs

Keywords

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