@inbook{a07119080d844dd4981e268b0b17890e,
title = "DNA probe detection within 3D hydrogel matrix in a hollow core photonic crystal fibre",
abstract = "In this paper, we report for the first time the detection of a Cy5-labelled DNA probe immobilised within a 3D hydrogel matrix formed, inside a hollow core Photonic Crystal Fibre (HC-PCF). We show both the sensitivity of fluorescence detection inside the HC-PCF using a supercontinuum light source and of the variation of the luminescence intensity with the concentration DNA probe within the hydrogel. The 3D hydrogel matrix is a network of polymer chains, which is expected to provide highly sensitive detection and selection of bio-molecules, in comparison with 2D coverage. The biocompatibility of hydrogel in the HC-PCF suggests numerous applications associated with immobilised DNA probe detection for point-of-care or remote systems.",
keywords = "biosensing, DNA, fluorescence, hollow core, hydrogel, Photonic crystal fibres, silanisation",
author = "Monika Rutowska and Jiadi Lu and Garcia-Gunning, \{Fatima C.\} and Ellis, \{Andrew D.\}",
year = "2011",
doi = "10.1117/12.886070",
language = "English",
isbn = "9780819482464",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "21st International Conference on Optical Fiber Sensors",
note = "21st International Conference on Optical Fiber Sensors ; Conference date: 15-05-2011 Through 19-05-2011",
}