DNA-templated assembly of a protein-functionalized nanogap electrode

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Abstract

The deoxyribonucleic acid (DNA) templated assembly of a protein-functionalized 10 nm gap electrode from suitably modified gold nanoparticles on a silicon wafer substrate was described. The DNA backbone served to template the assembly of DMSP-modified gold nanoparticles, which were subsequently enlarged and enjoined to form the electrode. The streptavidin-functionalized gas was subsequently recognized and bound selectively by a biotin modified gold nanoparticle localized in 10 nm gap. It was concluded that overall efficiency for formation of a streptavidin- functionalized 10 nm gap gold electrode on silicon wafer substrate was approximately 60%.

Original languageEnglish
Pages (from-to)1799-1803
Number of pages5
JournalAdvanced Materials
Volume16
Issue number20
DOIs
Publication statusPublished - 18 Oct 2004
Externally publishedYes

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