Dose-response relationship of atracurium besylate in the halothaneana-esthetised pig

G. D. Shorten; N. M. Gibbs

doi:10.1016/0034-5288(93)90116-W

Dose-response relationship of atracurium besylate in the halothaneana-esthetised pig

G. D. Shorten
, N. M. Gibbs

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The dose response relationship for the intermediateacting non-depolarising muscle relaxant, atracurium besylate in the pig was determined using evoked electromyography. An incremental dose technique was used in seven Large White/Landrace crossbred pigs anaesthetised with nitrous oxide and halothane. ED50 and ED95 were 510 ± 87 μg kg-1 and 1150 ± 270 μg kg-1, respectively. Although these values may represent an overestimate, they provide a reasonable guideline for the use of atracurium by veterinary anaesthetists. © 1993.

Original language	English (Ireland)
Pages (from-to)	392-393
Number of pages	2
Journal	Research in Veterinary Science
Volume	55
Issue number	3
DOIs	https://doi.org/10.1016/0034-5288(93)90116-W
Publication status	Published - 1993

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title = "Dose-response relationship of atracurium besylate in the halothaneana-esthetised pig",

abstract = "The dose response relationship for the intermediateacting non-depolarising muscle relaxant, atracurium besylate in the pig was determined using evoked electromyography. An incremental dose technique was used in seven Large White/Landrace crossbred pigs anaesthetised with nitrous oxide and halothane. ED50 and ED95 were 510 ± 87 μg kg-1 and 1150 ± 270 μg kg-1, respectively. Although these values may represent an overestimate, they provide a reasonable guideline for the use of atracurium by veterinary anaesthetists. {\textcopyright} 1993.",

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AB - The dose response relationship for the intermediateacting non-depolarising muscle relaxant, atracurium besylate in the pig was determined using evoked electromyography. An incremental dose technique was used in seven Large White/Landrace crossbred pigs anaesthetised with nitrous oxide and halothane. ED50 and ED95 were 510 ± 87 μg kg-1 and 1150 ± 270 μg kg-1, respectively. Although these values may represent an overestimate, they provide a reasonable guideline for the use of atracurium by veterinary anaesthetists. © 1993.

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Dose-response relationship of atracurium besylate in the halothaneana-esthetised pig

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