@inproceedings{425e110f517146459d5f759a351da473,
title = "Dual wavelengths inverse spatially offset Raman spectroscopy for bone characterization",
abstract = "Osteoporosis is a disease that weakens bones increasing the possibility of bone fracture. The gold standard to diagnose osteoporosis is measuring bone mineral density (BMD). Since BMD only partly determines the strength of the bone, more information on chemical composition and microstructure is needed. Here, we implemented a novel dual-wavelength inverse Spatially Offset Raman Spectroscopy (SORS) to characterize tissue chemical composition covering both the fingerprint and high-wavenumber regions. This system provides a greater probing depth keeping the spectrometer setting constant. The results from hydroxyapatite (HA) and water phantom demonstrate the potential of the Raman system to assess bone mineral and matrix quality in-vivo.",
keywords = "BMD, Hydration, Osteoporosis, Raman, SORS",
author = "Hui Ma and Rekha Gautam and \{Konugolu Venkata Sekar\}, Sanathana and Carrie O'Flynn and Patrick Henn and Stefan Andersson-Engels",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI 2023 ; Conference date: 28-01-2023 Through 29-01-2023",
year = "2023",
doi = "10.1117/12.2650089",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Caroline Boudoux and Tunnell, \{James W.\}",
booktitle = "Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI",
address = "United States",
}