TY - JOUR
T1 - Early diagnosis of primary Sjögrens syndrome
T2 - EULAR-SS task force clinical recommendations
AU - Brito-Zerón, Pilar
AU - Theander, Elke
AU - Baldini, Chiara
AU - Seror, Raphaèle
AU - Retamozo, Soledad
AU - Quartuccio, Luca
AU - Bootsma, Hendrika
AU - Bowman, Simon J.
AU - Dörner, Thomas
AU - Gottenberg, Jacques Eric
AU - Mariette, Xavier
AU - Bombardieri, Stefano
AU - De Vita, Salvatore
AU - Mandl, Thomas
AU - Ng, Wan Fai
AU - Kruize, Aike A.
AU - Tzioufas, Athanasios
AU - Vitali, Claudio
AU - Buyon, Jill
AU - Izmirly, Peter
AU - Fox, Robert
AU - Ramos-Casals, Manuel
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Sjögrens syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands, leading to generalized mucosal dryness. However, primary SjS may initially present with non-sicca (systemic) manifestations. When these features appear before the onset of an overt sicca syndrome, we may talk of an underlying occult SjS. The European League Against Rheumatism (EULAR) has promoted and supported an international collaborative study group (EULAR-SS Task Force) aimed at developing consensual recommendations to provide a homogeneous approach to the patient with primary SjS presenting with systemic involvement. This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis. Close collaboration with the different specialties involved through a comprehensive multidisciplinary approach is essential in SjS patients presenting with systemic involvements.
AB - Sjögrens syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands, leading to generalized mucosal dryness. However, primary SjS may initially present with non-sicca (systemic) manifestations. When these features appear before the onset of an overt sicca syndrome, we may talk of an underlying occult SjS. The European League Against Rheumatism (EULAR) has promoted and supported an international collaborative study group (EULAR-SS Task Force) aimed at developing consensual recommendations to provide a homogeneous approach to the patient with primary SjS presenting with systemic involvement. This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis. Close collaboration with the different specialties involved through a comprehensive multidisciplinary approach is essential in SjS patients presenting with systemic involvements.
KW - Anti-Ro/SS-A antibodies
KW - Classification criteria
KW - Early diagnosis
KW - ESSDAI
KW - Focal lymphocytic sialadenitis
KW - Sjögren syndrome
KW - Systemic activity
UR - https://www.scopus.com/pages/publications/84957431999
U2 - 10.1586/1744666X.2016.1109449
DO - 10.1586/1744666X.2016.1109449
M3 - Review article
C2 - 26691952
AN - SCOPUS:84957431999
SN - 1744-666X
VL - 12
SP - 137
EP - 156
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
IS - 2
ER -
