Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

Joanne M. Kelleher; Simon E. Lawrence; Humphrey A. Moynihan

doi:10.1039/b516716g

Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

School of Chemistry

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.

Original language	English
Pages (from-to)	327-332
Number of pages	6
Journal	CrystEngComm
Volume	8
Issue number	4
DOIs	https://doi.org/10.1039/b516716g
Publication status	Published - 2006

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title = "Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole",

abstract = "The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.",

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AU - Kelleher, Joanne M.

AU - Lawrence, Simon E.

AU - Moynihan, Humphrey A.

PY - 2006

Y1 - 2006

N2 - The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.

AB - The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.

UR - https://www.scopus.com/pages/publications/33646349770

U2 - 10.1039/b516716g

DO - 10.1039/b516716g

M3 - Article

AN - SCOPUS:33646349770

SN - 1466-8033

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SP - 327

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JO - CrystEngComm

JF - CrystEngComm

IS - 4

ER -

Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

Abstract

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