Effective induction of high-titer antibodies by viral vector vaccines

Simon J. Draper; Anne C. Moore; Anna L. Goodman; Carole A. Long; Anthony A. Holder; Sarah C. Gilbert; Fergal Hill; Adrian V.S. Hill

doi:10.1038/nm.1850

Effective induction of high-titer antibodies by viral vector vaccines

Simon J. Draper
, Anne C. Moore
, Anna L. Goodman
, Carole A. Long
, Anthony A. Holder
, Sarah C. Gilbert
, Fergal Hill
, Adrian V.S. Hill

School of Biochemistry and Cell Biology

University of Oxford
National Institutes of Health
Medical Research Council
Imaxio SA

Research output: Contribution to journal › Article › peer-review

Abstract

Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

Original language	English
Pages (from-to)	819-821
Number of pages	3
Journal	Nature Medicine
Volume	14
Issue number	8
DOIs	https://doi.org/10.1038/nm.1850
Publication status	Published - Aug 2008

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/nm.1850

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abstract = "Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.",

author = "Draper, \{Simon J.\} and Moore, \{Anne C.\} and Goodman, \{Anna L.\} and Long, \{Carole A.\} and Holder, \{Anthony A.\} and Gilbert, \{Sarah C.\} and Fergal Hill and Hill, \{Adrian V.S.\}",

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AU - Draper, Simon J.

AU - Moore, Anne C.

AU - Goodman, Anna L.

AU - Long, Carole A.

AU - Holder, Anthony A.

AU - Gilbert, Sarah C.

AU - Hill, Fergal

AU - Hill, Adrian V.S.

PY - 2008/8

Y1 - 2008/8

N2 - Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

AB - Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

UR - https://www.scopus.com/pages/publications/49149104386

U2 - 10.1038/nm.1850

DO - 10.1038/nm.1850

M3 - Article

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JO - Nature Medicine

JF - Nature Medicine

IS - 8

ER -

Effective induction of high-titer antibodies by viral vector vaccines

Abstract

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