Efficient kinetic bioresolution of 2-nitrocyclohexanol

Sinead E. Milner; Maude Brossat; Thomas S. Moody; Curtis J. Elcoate; Simon E. Lawrence; Anita R. Maguire

doi:10.1016/j.tetasy.2010.05.006

Efficient kinetic bioresolution of 2-nitrocyclohexanol

Sinead E. Milner
, Maude Brossat
, Thomas S. Moody
, Curtis J. Elcoate
, Simon E. Lawrence
, Anita R. Maguire

Research output: Contribution to journal › Article › peer-review

Abstract

The kinetic bioresolution of 2-nitrocyclohexanol 1 was investigated by screening a range of hydrolases both for enantioselective transesterification and for enantioselective hydrolysis of the corresponding acetate. By appropriate choice of biocatalyst and conditions, both enantiomers of cis and trans 2-nitrocyclohexanol 1 can be accessed in enantiopure form.

Original language	English
Pages (from-to)	1011-1016
Number of pages	6
Journal	Tetrahedron Asymmetry
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.tetasy.2010.05.006
Publication status	Published - 2010

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10.1016/j.tetasy.2010.05.006

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title = "Efficient kinetic bioresolution of 2-nitrocyclohexanol",

abstract = "The kinetic bioresolution of 2-nitrocyclohexanol 1 was investigated by screening a range of hydrolases both for enantioselective transesterification and for enantioselective hydrolysis of the corresponding acetate. By appropriate choice of biocatalyst and conditions, both enantiomers of cis and trans 2-nitrocyclohexanol 1 can be accessed in enantiopure form.",

author = "Milner, \{Sinead E.\} and Maude Brossat and Moody, \{Thomas S.\} and Elcoate, \{Curtis J.\} and Lawrence, \{Simon E.\} and Maguire, \{Anita R.\}",

year = "2010",

doi = "10.1016/j.tetasy.2010.05.006",

language = "English",

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journal = "Tetrahedron Asymmetry",

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T1 - Efficient kinetic bioresolution of 2-nitrocyclohexanol

AU - Milner, Sinead E.

AU - Brossat, Maude

AU - Moody, Thomas S.

AU - Elcoate, Curtis J.

AU - Lawrence, Simon E.

AU - Maguire, Anita R.

PY - 2010

Y1 - 2010

N2 - The kinetic bioresolution of 2-nitrocyclohexanol 1 was investigated by screening a range of hydrolases both for enantioselective transesterification and for enantioselective hydrolysis of the corresponding acetate. By appropriate choice of biocatalyst and conditions, both enantiomers of cis and trans 2-nitrocyclohexanol 1 can be accessed in enantiopure form.

AB - The kinetic bioresolution of 2-nitrocyclohexanol 1 was investigated by screening a range of hydrolases both for enantioselective transesterification and for enantioselective hydrolysis of the corresponding acetate. By appropriate choice of biocatalyst and conditions, both enantiomers of cis and trans 2-nitrocyclohexanol 1 can be accessed in enantiopure form.

UR - https://www.scopus.com/pages/publications/77954309578

U2 - 10.1016/j.tetasy.2010.05.006

DO - 10.1016/j.tetasy.2010.05.006

M3 - Article

AN - SCOPUS:77954309578

SN - 0957-4166

VL - 21

SP - 1011

EP - 1016

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 8

ER -

Efficient kinetic bioresolution of 2-nitrocyclohexanol

Abstract

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