Efficient kinetic resolution of 2-benzenesulfonylcyclopentanone derivatives [J. Mol. Catal., 1 (1996) 115-126]

Anita R. Maguire; Leonard L. Kelleher; George Ferguson

doi:10.1016/S1381-1177(96)00026-4

Efficient kinetic resolution of 2-benzenesulfonylcyclopentanone derivatives [J. Mol. Catal., 1 (1996) 115-126]

Anita R. Maguire
, Leonard L. Kelleher
, George Ferguson

Research output: Contribution to journal › Comment/Debate

Abstract

Efficient kinetic resolution of 2-benzenesulfonylcyclopentanones 1, bearing 3-alkyl, 3-aryl, or 3-benzyl substituents, has been achieved by bakers' yeast mediated reduction. With the unsubstituted 2-benzenesulfonylcyclopentanone 1a, efficient asymmetric reduction to form (1S,2R)-cis-2-benzenesulfonylcyclopentanol 2a is observed under the same conditions. Excellent enantioselectivities (up to >95% ee) are obtained.

Original language	English
Pages (from-to)	147-158
Number of pages	12
Journal	Journal of Molecular Catalysis - B Enzymatic
Volume	2
Issue number	2-3
DOIs	https://doi.org/10.1016/S1381-1177(96)00026-4
Publication status	Published - 1996

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title = "Efficient kinetic resolution of 2-benzenesulfonylcyclopentanone derivatives [J. Mol. Catal., 1 (1996) 115-126]",

abstract = "Efficient kinetic resolution of 2-benzenesulfonylcyclopentanones 1, bearing 3-alkyl, 3-aryl, or 3-benzyl substituents, has been achieved by bakers' yeast mediated reduction. With the unsubstituted 2-benzenesulfonylcyclopentanone 1a, efficient asymmetric reduction to form (1S,2R)-cis-2-benzenesulfonylcyclopentanol 2a is observed under the same conditions. Excellent enantioselectivities (up to >95\% ee) are obtained.",

author = "Maguire, \{Anita R.\} and Kelleher, \{Leonard L.\} and George Ferguson",

year = "1996",

doi = "10.1016/S1381-1177(96)00026-4",

language = "English",

volume = "2",

pages = "147--158",

journal = "Journal of Molecular Catalysis - B Enzymatic",

issn = "1381-1177",

publisher = "Elsevier",

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T1 - Efficient kinetic resolution of 2-benzenesulfonylcyclopentanone derivatives [J. Mol. Catal., 1 (1996) 115-126]

AU - Maguire, Anita R.

AU - Kelleher, Leonard L.

AU - Ferguson, George

PY - 1996

Y1 - 1996

N2 - Efficient kinetic resolution of 2-benzenesulfonylcyclopentanones 1, bearing 3-alkyl, 3-aryl, or 3-benzyl substituents, has been achieved by bakers' yeast mediated reduction. With the unsubstituted 2-benzenesulfonylcyclopentanone 1a, efficient asymmetric reduction to form (1S,2R)-cis-2-benzenesulfonylcyclopentanol 2a is observed under the same conditions. Excellent enantioselectivities (up to >95% ee) are obtained.

AB - Efficient kinetic resolution of 2-benzenesulfonylcyclopentanones 1, bearing 3-alkyl, 3-aryl, or 3-benzyl substituents, has been achieved by bakers' yeast mediated reduction. With the unsubstituted 2-benzenesulfonylcyclopentanone 1a, efficient asymmetric reduction to form (1S,2R)-cis-2-benzenesulfonylcyclopentanol 2a is observed under the same conditions. Excellent enantioselectivities (up to >95% ee) are obtained.

UR - https://www.scopus.com/pages/publications/0030569501

U2 - 10.1016/S1381-1177(96)00026-4

DO - 10.1016/S1381-1177(96)00026-4

M3 - Comment/Debate

AN - SCOPUS:0030569501

SN - 1381-1177

VL - 2

SP - 147

EP - 158

JO - Journal of Molecular Catalysis - B Enzymatic

JF - Journal of Molecular Catalysis - B Enzymatic

IS - 2-3

ER -

Efficient kinetic resolution of 2-benzenesulfonylcyclopentanone derivatives [J. Mol. Catal., 1 (1996) 115-126]

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