Efficient S-Acylation of Thiourea

David Jones; Simon E. Lawrence; Timothy P. O'Sullivan

doi:10.1055/s-0037-1610370

Efficient S-Acylation of Thiourea

Munster Technological University

Research output: Contribution to journal › Article › peer-review

Abstract

Efficient S -acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

Original language	Undefined/Unknown
Article number	so-2018-d0048-l
Pages (from-to)	263-267
Number of pages	5
Journal	SynOpen
Volume	2
Issue number	4
DOIs	https://doi.org/10.1055/s-0037-1610370
Publication status	Published - 18 Oct 2018

Keywords

isothiourea
organosulfur
sulfur transfer
thiourea
Organic synthesis

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10.1055/s-0037-1610370

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title = "Efficient S-Acylation of Thiourea",

abstract = "Efficient S -acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.",

keywords = "isothiourea, organosulfur, sulfur transfer, thiourea, Organic synthesis",

author = "David Jones and Lawrence, \{Simon E.\} and O'Sullivan, \{Timothy P.\}",

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year = "2018",

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doi = "10.1055/s-0037-1610370",

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AU - Jones, David

AU - Lawrence, Simon E.

AU - O'Sullivan, Timothy P.

N1 - Publisher Copyright: © Georg Thieme Verlag Stuttgart, New York.

PY - 2018/10/18

Y1 - 2018/10/18

N2 - Efficient S -acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

AB - Efficient S -acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

KW - isothiourea

KW - organosulfur

KW - sulfur transfer

KW - thiourea

KW - Organic synthesis

UR - https://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610370

UR - https://www.scopus.com/pages/publications/85101298497

U2 - 10.1055/s-0037-1610370

DO - 10.1055/s-0037-1610370

M3 - Article

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EP - 267

JO - SynOpen

JF - SynOpen

IS - 4

M1 - so-2018-d0048-l

ER -

Efficient S-Acylation of Thiourea

Abstract

Keywords

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