TY - JOUR
T1 - Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic
T2 - An international, multicenter, comparative cohort study
AU - COVIDSurg Collaborative
AU - Glasbey, James C.
AU - Nepogodiev, Dmitri
AU - Simoes, Joana F.F.
AU - Omar, Omar
AU - Li, Elizabeth
AU - Venn, Mary L.
AU - Abou Chaar, Mohammad K.
AU - Capizzi, Vita
AU - Chaudhry, Daoud
AU - Desai, Anant
AU - Edwards, Jonathan G.
AU - Evans, Jonathan P.
AU - Fiore, Marco
AU - Videria, Jose Flavio
AU - Ford, Samuel J.
AU - Ganly, Ian
AU - Griffiths, Ewen A.
AU - Gujjuri, Rohan R.
AU - Kolias, Angelos G.
AU - Kaafarani, Haytham M.A.
AU - Minaya-Bravo, Ana
AU - McKay, Siobhan C.
AU - Mohan, Helen M.
AU - Roberts, Keith J.
AU - Miguel-Méndez, Carlos San
AU - Pockney, Peter
AU - Shaw, Richard
AU - Smart, Neil J.
AU - Stewart, Grant D.
AU - Sundar, Sudha
AU - Vidya, Raghavan
AU - Bhangu, Aneel A.
AU - Siaw-Acheampong, Kwabena
AU - Bywater, Edward
AU - Dawson, Brett E.
AU - Heritage, Emily
AU - Jones, Conor S.
AU - Kamarajah, Sivesh K.
AU - Khatri, Chetan
AU - Khaw, Rachel A.
AU - Keatley, James M.
AU - Knight, Andrew
AU - Lawday, Samuel
AU - Mann, Harvinder S.
AU - Marson, Ella J.
AU - McLean, Kenneth A.
AU - Mills, Emily C.
AU - Corrigan, M.
AU - Sheahan, P.
AU - Barry, C.
N1 - Publisher Copyright:
Copyright © 2020 American Society of Clinical Oncology. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
AB - PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
UR - https://www.scopus.com/pages/publications/85098324528
U2 - 10.1200/JCO.20.01933
DO - 10.1200/JCO.20.01933
M3 - Article
C2 - 33021869
AN - SCOPUS:85098324528
SN - 0732-183X
VL - 39
SP - 66
EP - 78
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 1
ER -
SDG 3 Good Health and Well-being