TY - CHAP
T1 - Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry This journal is © The Royal Society of Chemistry 2011
AU - Chemistry, Biomolecular
AU - Reen, F. Jerry
AU - Clarke, Sarah L.
AU - Legendre, Claire
AU - McSweeney, Christina M.
AU - Eccles, Kevin S.
AU - Lawrence, Simon E.
AU - O'Gara, Fergal
AU - McGlacken, Gerard P.
PY - 2011
Y1 - 2011
N2 - 2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour. © 2012 The Royal Society of Chemistry.
AB - 2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour. © 2012 The Royal Society of Chemistry.
UR - http://xlink.rsc.org/?DOI=c2ob26823j
UR - https://www.mendeley.com/catalogue/56a46f93-1380-32d1-a0f5-68ff01d25e56/
M3 - Chapter
C2 - 23051988
SN - 3900155094350
T3 - Organic & Biomolecular Chemistry
SP - 1
EP - 4
BT - Organic & Biomolecular Chemistry
ER -