Endoscopic healing in IBD: Still the target to achieve?

Andrea Buda; Tommaso Pessarelli; Giovanni Aldinio; Manuela De Bona; Marietta Iacucci; Gian Eugenio Tontini

doi:10.1016/j.dld.2025.02.009

Endoscopic healing in IBD: Still the target to achieve?

Andrea Buda
, Tommaso Pessarelli
, Giovanni Aldinio
, Manuela De Bona
, Marietta Iacucci
, Gian Eugenio Tontini

Research output: Contribution to journal › Comment/Debate

Abstract

Mucosal healing is the mainstream goal of modern treat-to-target strategy as it is associated with a significantly more favorable disease course in IBD patients with either ulcerative colitis or Crohn's disease. Recent advances in endoscopic imaging technologies have overcome the traditional concept of mucosal healing assessed with conventional white light imaging, allowing for multiple levels of endoscopic healing up to the boundaries of molecular and functional evaluation. In this review, we focused on conventional and emerging strategies to assess endoscopic healing in ulcerative colitis and ileocolonic Crohn's disease, examining their pros and cons in real life practice.

Original language	English
Pages (from-to)	519-526
Number of pages	8
Journal	Digestive and Liver Disease
Volume	57
Issue number	5
DOIs	https://doi.org/10.1016/j.dld.2025.02.009
Publication status	Published - May 2025

Keywords

Chromoendoscopy
Confocal laser endomicroscopy
Crohn's disease
Endoscopic healing
Inflammatory bowel diseases
Molecular imaging
Mucosal healing
Ulcerative colitis

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10.1016/j.dld.2025.02.009

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@article{182ed18df885441bad7bead1f93a39fc,

title = "Endoscopic healing in IBD: Still the target to achieve?",

abstract = "Mucosal healing is the mainstream goal of modern treat-to-target strategy as it is associated with a significantly more favorable disease course in IBD patients with either ulcerative colitis or Crohn's disease. Recent advances in endoscopic imaging technologies have overcome the traditional concept of mucosal healing assessed with conventional white light imaging, allowing for multiple levels of endoscopic healing up to the boundaries of molecular and functional evaluation. In this review, we focused on conventional and emerging strategies to assess endoscopic healing in ulcerative colitis and ileocolonic Crohn's disease, examining their pros and cons in real life practice.",

keywords = "Chromoendoscopy, Confocal laser endomicroscopy, Crohn's disease, Endoscopic healing, Inflammatory bowel diseases, Molecular imaging, Mucosal healing, Ulcerative colitis",

author = "Andrea Buda and Tommaso Pessarelli and Giovanni Aldinio and \{De Bona\}, Manuela and Marietta Iacucci and Tontini, \{Gian Eugenio\}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

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doi = "10.1016/j.dld.2025.02.009",

language = "English",

volume = "57",

pages = "519--526",

journal = "Digestive and Liver Disease",

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TY - JOUR

T1 - Endoscopic healing in IBD

T2 - Still the target to achieve?

AU - Buda, Andrea

AU - Pessarelli, Tommaso

AU - Aldinio, Giovanni

AU - De Bona, Manuela

AU - Iacucci, Marietta

AU - Tontini, Gian Eugenio

PY - 2025/5

Y1 - 2025/5

N2 - Mucosal healing is the mainstream goal of modern treat-to-target strategy as it is associated with a significantly more favorable disease course in IBD patients with either ulcerative colitis or Crohn's disease. Recent advances in endoscopic imaging technologies have overcome the traditional concept of mucosal healing assessed with conventional white light imaging, allowing for multiple levels of endoscopic healing up to the boundaries of molecular and functional evaluation. In this review, we focused on conventional and emerging strategies to assess endoscopic healing in ulcerative colitis and ileocolonic Crohn's disease, examining their pros and cons in real life practice.

AB - Mucosal healing is the mainstream goal of modern treat-to-target strategy as it is associated with a significantly more favorable disease course in IBD patients with either ulcerative colitis or Crohn's disease. Recent advances in endoscopic imaging technologies have overcome the traditional concept of mucosal healing assessed with conventional white light imaging, allowing for multiple levels of endoscopic healing up to the boundaries of molecular and functional evaluation. In this review, we focused on conventional and emerging strategies to assess endoscopic healing in ulcerative colitis and ileocolonic Crohn's disease, examining their pros and cons in real life practice.

KW - Chromoendoscopy

KW - Confocal laser endomicroscopy

KW - Crohn's disease

KW - Endoscopic healing

KW - Inflammatory bowel diseases

KW - Molecular imaging

KW - Mucosal healing

KW - Ulcerative colitis

UR - https://www.scopus.com/pages/publications/105000055987

U2 - 10.1016/j.dld.2025.02.009

DO - 10.1016/j.dld.2025.02.009

M3 - Comment/Debate

C2 - 40074573

AN - SCOPUS:105000055987

SN - 1590-8658

VL - 57

SP - 519

EP - 526

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

IS - 5

ER -

Endoscopic healing in IBD: Still the target to achieve?

Abstract

Keywords

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