TY - JOUR
T1 - Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system
AU - Segarra, Marta
AU - Aburto, Maria R.
AU - Cop, Florian
AU - Llaó-Cid, Cecília
AU - Härtl, Ricarda
AU - Damm, Miriam
AU - Bethani, Ioanna
AU - Parrilla, Marta
AU - Husainie, Dewi
AU - Schänzer, Anne
AU - Schlierbach, Hannah
AU - Acker, Till
AU - Mohr, Laura
AU - Torres-Masjoan, Laia
AU - Ritter, Mathias
AU - Acker-Palmer, Amparo
N1 - Publisher Copyright:
2017 © The Authors
PY - 2018/8/24
Y1 - 2018/8/24
N2 - The architecture of the neurovascular unit (NVU) is controlled by the communication of neurons, glia, and vascular cells. We found that the neuronal guidance cue reelin possesses proangiogenic activities that ensure the communication of endothelial cells (ECs) with the glia to control neuronal migration and the establishment of the blood-brain barrier in the mouse brain. Apolipoprotein E receptor 2 (ApoER2) and Disabled1 (Dab1) expressed in ECs are required for vascularization of the retina and the cerebral cortex. Deletion of Dab1 in ECs leads to a reduced secretion of laminin-a4 and decreased activation of integrin-b1 in glial cells, which in turn control neuronal migration and barrier properties of the NVU. Thus, reelin signaling in the endothelium is an instructive and integrative cue essential for neuro-glia-vascular communication.
AB - The architecture of the neurovascular unit (NVU) is controlled by the communication of neurons, glia, and vascular cells. We found that the neuronal guidance cue reelin possesses proangiogenic activities that ensure the communication of endothelial cells (ECs) with the glia to control neuronal migration and the establishment of the blood-brain barrier in the mouse brain. Apolipoprotein E receptor 2 (ApoER2) and Disabled1 (Dab1) expressed in ECs are required for vascularization of the retina and the cerebral cortex. Deletion of Dab1 in ECs leads to a reduced secretion of laminin-a4 and decreased activation of integrin-b1 in glial cells, which in turn control neuronal migration and barrier properties of the NVU. Thus, reelin signaling in the endothelium is an instructive and integrative cue essential for neuro-glia-vascular communication.
UR - https://www.scopus.com/pages/publications/85052119530
U2 - 10.1126/science.aao2861
DO - 10.1126/science.aao2861
M3 - Article
C2 - 30139844
AN - SCOPUS:85052119530
SN - 0036-8075
VL - 361
JO - Science
JF - Science
IS - 6404
M1 - eaao2861
ER -
