TY - JOUR
T1 - Enzyme reactions in the presence of cyclodextrins
T2 - biosensors and enzyme assays
AU - Luong, John H.T.
AU - Brown, R. Stephen
AU - Male, Keith B.
AU - Cattaneo, Maurice V.
AU - Zhao, Shishan
PY - 1995/11
Y1 - 1995/11
N2 - Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivaties, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors. In addition, the solubilization of polynuclear aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene, by cyclodextrins has enabled the detection of these important environmental contaminants.
AB - Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivaties, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors. In addition, the solubilization of polynuclear aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene, by cyclodextrins has enabled the detection of these important environmental contaminants.
UR - https://www.scopus.com/pages/publications/0028864330
U2 - 10.1016/S0167-7799(00)89002-2
DO - 10.1016/S0167-7799(00)89002-2
M3 - Article
C2 - 7488360
AN - SCOPUS:0028864330
SN - 0167-7799
VL - 13
SP - 457
EP - 463
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 11
ER -