Enzyme reactions in the presence of cyclodextrins: biosensors and enzyme assays

John H.T. Luong; R. Stephen Brown; Keith B. Male; Maurice V. Cattaneo; Shishan Zhao

doi:10.1016/S0167-7799(00)89002-2

Enzyme reactions in the presence of cyclodextrins: biosensors and enzyme assays

John H.T. Luong
, R. Stephen Brown
, Keith B. Male
, Maurice V. Cattaneo
, Shishan Zhao

National Research Council of Canada

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivaties, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors. In addition, the solubilization of polynuclear aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene, by cyclodextrins has enabled the detection of these important environmental contaminants.

Original language	English
Pages (from-to)	457-463
Number of pages	7
Journal	Trends in Biotechnology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1016/S0167-7799(00)89002-2
Publication status	Published - Nov 1995
Externally published	Yes

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10.1016/S0167-7799(00)89002-2

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title = "Enzyme reactions in the presence of cyclodextrins: biosensors and enzyme assays",

abstract = "Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivaties, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors. In addition, the solubilization of polynuclear aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene, by cyclodextrins has enabled the detection of these important environmental contaminants.",

author = "Luong, \{John H.T.\} and Brown, \{R. Stephen\} and Male, \{Keith B.\} and Cattaneo, \{Maurice V.\} and Shishan Zhao",

year = "1995",

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doi = "10.1016/S0167-7799(00)89002-2",

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AU - Luong, John H.T.

AU - Brown, R. Stephen

AU - Male, Keith B.

AU - Cattaneo, Maurice V.

AU - Zhao, Shishan

PY - 1995/11

Y1 - 1995/11

N2 - Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivaties, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors. In addition, the solubilization of polynuclear aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene, by cyclodextrins has enabled the detection of these important environmental contaminants.

AB - Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivaties, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with cyclodextrins, they can be used in enzymatic assays and in the construction of mediated biosensors. In addition, the solubilization of polynuclear aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene, by cyclodextrins has enabled the detection of these important environmental contaminants.

UR - https://www.scopus.com/pages/publications/0028864330

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VL - 13

SP - 457

EP - 463

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 11

ER -

Enzyme reactions in the presence of cyclodextrins: biosensors and enzyme assays

Abstract

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