Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen

Tu Anh N. Pham; Simon Clare; David Goulding; Julia M. Arasteh; Mark D. Stares; Hilary P. Browne; Jacqueline A. Keane; Andrew J. Page; Natsuhiko Kumasaka; Leanne Kane; Lynda Mottram; Katherine Harcourt; Christine Hale; Mark J. Arends; Daniel J. Gaffney; Gordon Dougan; Trevor D. Lawley

doi:10.1016/j.chom.2014.08.017

Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen

Tu Anh N. Pham
, Simon Clare
, David Goulding
, Julia M. Arasteh
, Mark D. Stares
, Hilary P. Browne
, Jacqueline A. Keane
, Andrew J. Page
, Natsuhiko Kumasaka
, Leanne Kane
, Lynda Mottram
, Katherine Harcourt
, Christine Hale
, Mark J. Arends
, Daniel J. Gaffney
, Gordon Dougan
, Trevor D. Lawley

Research output: Contribution to journal › Article › peer-review

Abstract

Il22ra1^-/- mice succumb to enterococcal dissemination during C. rodentium infectionE. faecalis expands during C. rodentium-induced dysbiosis and invades epithelial cellsOrganoid IL-22RA1 RNA-seq reveals diverse antimicrobial and glycosylation factorsIntestinal fucosylation enhances colonization resistance to E.

Original language	English
Pages (from-to)	504-516
Number of pages	13
Journal	Cell Host and Microbe
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2014.08.017
Publication status	Published - 8 Oct 2014
Externally published	Yes

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10.1016/j.chom.2014.08.017

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Pham, T. A. N., Clare, S., Goulding, D., Arasteh, J. M., Stares, M. D., Browne, H. P., Keane, J. A., Page, A. J., Kumasaka, N., Kane, L., Mottram, L., Harcourt, K., Hale, C., Arends, M. J., Gaffney, D. J., Dougan, G., & Lawley, T. D. (2014). Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen. Cell Host and Microbe, 16(4), 504-516. https://doi.org/10.1016/j.chom.2014.08.017

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title = "Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen",

abstract = "Il22ra1-/- mice succumb to enterococcal dissemination during C. rodentium infectionE. faecalis expands during C. rodentium-induced dysbiosis and invades epithelial cellsOrganoid IL-22RA1 RNA-seq reveals diverse antimicrobial and glycosylation factorsIntestinal fucosylation enhances colonization resistance to E.",

author = "Pham, \{Tu Anh N.\} and Simon Clare and David Goulding and Arasteh, \{Julia M.\} and Stares, \{Mark D.\} and Browne, \{Hilary P.\} and Keane, \{Jacqueline A.\} and Page, \{Andrew J.\} and Natsuhiko Kumasaka and Leanne Kane and Lynda Mottram and Katherine Harcourt and Christine Hale and Arends, \{Mark J.\} and Gaffney, \{Daniel J.\} and Gordon Dougan and Lawley, \{Trevor D.\}",

note = "Publisher Copyright: {\textcopyright} 2014 The Authors.",

year = "2014",

month = oct,

day = "8",

doi = "10.1016/j.chom.2014.08.017",

language = "English",

volume = "16",

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journal = "Cell Host and Microbe",

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}

Pham, TAN, Clare, S, Goulding, D, Arasteh, JM, Stares, MD, Browne, HP, Keane, JA, Page, AJ, Kumasaka, N, Kane, L, Mottram, L, Harcourt, K, Hale, C, Arends, MJ, Gaffney, DJ, Dougan, G & Lawley, TD 2014, 'Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen', Cell Host and Microbe, vol. 16, no. 4, pp. 504-516. https://doi.org/10.1016/j.chom.2014.08.017

TY - JOUR

T1 - Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen

AU - Pham, Tu Anh N.

AU - Clare, Simon

AU - Goulding, David

AU - Arasteh, Julia M.

AU - Stares, Mark D.

AU - Browne, Hilary P.

AU - Keane, Jacqueline A.

AU - Page, Andrew J.

AU - Kumasaka, Natsuhiko

AU - Kane, Leanne

AU - Mottram, Lynda

AU - Harcourt, Katherine

AU - Hale, Christine

AU - Arends, Mark J.

AU - Gaffney, Daniel J.

AU - Dougan, Gordon

AU - Lawley, Trevor D.

PY - 2014/10/8

Y1 - 2014/10/8

N2 - Il22ra1-/- mice succumb to enterococcal dissemination during C. rodentium infectionE. faecalis expands during C. rodentium-induced dysbiosis and invades epithelial cellsOrganoid IL-22RA1 RNA-seq reveals diverse antimicrobial and glycosylation factorsIntestinal fucosylation enhances colonization resistance to E.

AB - Il22ra1-/- mice succumb to enterococcal dissemination during C. rodentium infectionE. faecalis expands during C. rodentium-induced dysbiosis and invades epithelial cellsOrganoid IL-22RA1 RNA-seq reveals diverse antimicrobial and glycosylation factorsIntestinal fucosylation enhances colonization resistance to E.

UR - https://www.scopus.com/pages/publications/84908075358

U2 - 10.1016/j.chom.2014.08.017

DO - 10.1016/j.chom.2014.08.017

M3 - Article

C2 - 25263220

AN - SCOPUS:84908075358

SN - 1931-3128

VL - 16

SP - 504

EP - 516

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen

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