Erratum: CRISPR for cystic fibrosis: Advances and insights from a systematic review (Molecular Therapy (2025) 33(9) (4091–4112), (S1525001625004721), (10.1016/j.ymthe.2025.06.021))

(Molecular Therapy 33, 4091–4112; September 2025) The originally published version of this review included some typographical errors that have now been corrected online, along with minor rephrasing for clarity. For consistency with other sections of the manuscript, the following text has been removed from the “HDR mechanism and applications for CF-causing in-frame and nonsense mutations” section: • “For the definitions of NHEJ and MMEJ we refer to Riesenberg et al., who describe NHEJ as the integration of <2 bp MHs, and MMEJ as the integration of ≥2 bp MH.”The citation to the reference that was previously attached to this sentence has been moved to the end of the following sentence: “The frequency of spontaneous HDR-recombination events, however, is significantly low (1 in 10⁶–10⁹ cells) and often outweighed by NHEJ or MH-mediated end joining (MMEJ) events, that result in high levels of indel formation.” The references have been renumbered to reflect this change. The following text has been removed from the “Base-editing mechanism and applications for CF-causing splicing, in-frame, and nonsense mutations” section: • “For adenine base editing, it is proposed that following deamination of target adenine(s) within the protospacer sequence, and a nick on the non-deaminated strand, base excision repair (BER) and/or SSB repair (SSBR) are triggered, resulting in the desired A•T-to-G•C conversion (Figures 2A–2G).”• “Nick-induced synthesis of the non-deaminated strand, however, may also be initiated by mismatch repair (MMR), which would excise the mismatched base and facilitate DNA resynthesis.”In Table 3, row 2, “G54X” has been updated to “G542X.” The legend of Figure 2C has been updated. The corrected text now reads “(C) nCas9-mediated nicking of the non-edited strand on the 5′ side of the mismatch guides mismatch repair (MMR).” Figure 3 has been updated to change the typos “Cas9n” to “nCas9” and “editing” to “edit.” Figure 4 has been updated to fix an error in the pie chart of allelic frequencies in (I). The legend of Figure 4I has also been updated. The corrected text now reads “(I) (Left) Allele frequencies of the CF-causing mutations targeted in the studies under review (www.CFTR2.org); speckled pattern signifies all other CF-causing mutations. (Right) Distribution of the research articles in this review per CF-causing mutation.” The authors apologize for these errors.[Figure