Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy

Neda Haj-Hosseini; S. Andersson-Engels; K. Wårdell

doi:10.1007/978-3-540-69367-3_97

Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy

Neda Haj-Hosseini
, S. Andersson-Engels
, K. Wårdell

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.

Original language	English
Title of host publication	14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008
Publisher	Springer Verlag
Pages	363-366
Number of pages	4
ISBN (Print)	9783540693666
DOIs	https://doi.org/10.1007/978-3-540-69367-3_97
Publication status	Published - 2008
Externally published	Yes

Publication series

Name	IFMBE Proceedings
Volume	20 IFMBE
ISSN (Print)	1680-0737

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

Keywords

5-aminolevulinic acid induced fluorescence
Fluorescence spectroscopy
Glioma resection
Intraoperative optical guide
Pulsed laser modulation

Access to Document

10.1007/978-3-540-69367-3_97

Cite this

@inproceedings{e0e5a75b8e524d8683685bcdbadaf305,

title = "Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy",

abstract = "A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.",

keywords = "5-aminolevulinic acid induced fluorescence, Fluorescence spectroscopy, Glioma resection, Intraoperative optical guide, Pulsed laser modulation",

author = "Neda Haj-Hosseini and S. Andersson-Engels and K. W{\aa}rdell",

year = "2008",

doi = "10.1007/978-3-540-69367-3\_97",

language = "English",

isbn = "9783540693666",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

pages = "363--366",

booktitle = "14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008",

address = "Germany",

}

Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy. / Haj-Hosseini, Neda; Andersson-Engels, S.; Wårdell, K.
14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008. Springer Verlag, 2008. p. 363-366 (IFMBE Proceedings; Vol. 20 IFMBE).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

TY - GEN

T1 - Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy

AU - Haj-Hosseini, Neda

AU - Andersson-Engels, S.

AU - Wårdell, K.

PY - 2008

Y1 - 2008

N2 - A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.

AB - A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.

KW - 5-aminolevulinic acid induced fluorescence

KW - Fluorescence spectroscopy

KW - Glioma resection

KW - Intraoperative optical guide

KW - Pulsed laser modulation

UR - https://www.scopus.com/pages/publications/78049444201

U2 - 10.1007/978-3-540-69367-3_97

DO - 10.1007/978-3-540-69367-3_97

M3 - Conference proceeding

AN - SCOPUS:78049444201

SN - 9783540693666

T3 - IFMBE Proceedings

SP - 363

EP - 366

BT - 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008

PB - Springer Verlag

ER -

Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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Cite this