Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

Colm Ó Tuathaigh

doi:10.1016/j.bbr.2007.07.006

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

Colm Ó Tuathaigh

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.

Original language	Undefined/Unknown
Journal	Behavioural Brain Research
DOIs	https://doi.org/10.1016/j.bbr.2007.07.006
Publication status	Published - 12 Jul 2007

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10.1016/j.bbr.2007.07.006

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title = "Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.",

abstract = "Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.",

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doi = "10.1016/j.bbr.2007.07.006",

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AB - Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.

UR - https://doi.org/10.1016/j.bbr.2007.07.006

U2 - 10.1016/j.bbr.2007.07.006

DO - 10.1016/j.bbr.2007.07.006

M3 - Article

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SN - 0166-4328

JO - Behavioural Brain Research

JF - Behavioural Brain Research

ER -

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

Abstract

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