Expression of growth differentiation factor-5 in the developing and adult rat brain

Gerard W. O'Keeffe; Michael Hanke; Jens Pohl; Aideen M. Sullivan

doi:10.1016/j.devbrainres.2004.04.004

Expression of growth differentiation factor-5 in the developing and adult rat brain

Gerard W. O'Keeffe
, Michael Hanke
, Jens Pohl
, Aideen M. Sullivan

School of Medicine

Biopharm GmbH

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.

Original language	English
Pages (from-to)	199-202
Number of pages	4
Journal	Developmental Brain Research
Volume	151
Issue number	1-2
DOIs	https://doi.org/10.1016/j.devbrainres.2004.04.004
Publication status	Published - 19 Jul 2004

Keywords

BMP
bone morphogenetic protein
Bone morphogenetic protein
BSA
Development and regeneration
Dopaminergic neuron
Growth/differentiation factor-5
Neurotrophic factors: expression and regulation
Parkinson's disease
Transforming growth factor-βs

Access to Document

10.1016/j.devbrainres.2004.04.004

Cite this

@article{e3aecbf2234f479f963cd498a7e68a3e,

title = "Expression of growth differentiation factor-5 in the developing and adult rat brain",

abstract = "Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.",

keywords = "BMP, bone morphogenetic protein, Bone morphogenetic protein, BSA, Development and regeneration, Dopaminergic neuron, Growth/differentiation factor-5, Neurotrophic factors: expression and regulation, Parkinson's disease, Transforming growth factor-βs",

author = "O'Keeffe, \{Gerard W.\} and Michael Hanke and Jens Pohl and Sullivan, \{Aideen M.\}",

year = "2004",

month = jul,

day = "19",

doi = "10.1016/j.devbrainres.2004.04.004",

language = "English",

volume = "151",

pages = "199--202",

journal = "Developmental Brain Research",

issn = "0165-3806",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Expression of growth differentiation factor-5 in the developing and adult rat brain

AU - O'Keeffe, Gerard W.

AU - Hanke, Michael

AU - Pohl, Jens

AU - Sullivan, Aideen M.

PY - 2004/7/19

Y1 - 2004/7/19

N2 - Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.

AB - Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.

KW - BMP

KW - bone morphogenetic protein

KW - Bone morphogenetic protein

KW - BSA

KW - Development and regeneration

KW - Dopaminergic neuron

KW - Growth/differentiation factor-5

KW - Neurotrophic factors: expression and regulation

KW - Parkinson's disease

KW - Transforming growth factor-βs

UR - https://www.scopus.com/pages/publications/3042789545

U2 - 10.1016/j.devbrainres.2004.04.004

DO - 10.1016/j.devbrainres.2004.04.004

M3 - Article

C2 - 15246706

AN - SCOPUS:3042789545

SN - 0165-3806

VL - 151

SP - 199

EP - 202

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 1-2

ER -

Expression of growth differentiation factor-5 in the developing and adult rat brain

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this