Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

Marie Isabel Rasmussen; Mathias Lühr Hansen; Gerhard Pichler; Eugene Dempsey; Adelina Pellicer; Afif EL-Khuffash; Shashidhar A; Salvador Piris-Borregas; Miguel Alsina; Merih Cetinkaya; Lina Chalak; Hilal Özkan; Mariana Baserga; Jan Sirc; Hans Fuchs; Ebru Ergenekon; Luis Arruza; Amit Mathur; Martin Stocker; Olalla Otero Vaccarello; Tomasz Szczapa; Kosmas Sarafidis; Barbara Królak-Olejnik; Asli Memisoglu; Hallvard Reigstad; Elżbieta Rafińska-Ważny; Eleftheria Hatzidaki; Zhang Peng; Despoina Gkentzi; Renaud Viellevoye; Julie De Buyst; Emmanuele Mastretta; Ping Wang; Gitte Holst Hahn; Lars Bender; Luc Cornette; Jakub Tkaczyk; Ruth del Rio; Monica Fumagalli; Evangelia Papathoma; Maria Wilinska; Gunnar Naulaers; Iwona Sadowska-Krawczenko; Chantal Lecart; María Luz Couce; Siv Fredly; Anne Marie Heuchan; Tanja Karen; Gorm Greisen

doi:10.3389/fped.2021.647880

Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

Marie Isabel Rasmussen
, Mathias Lühr Hansen
, Gerhard Pichler
, Eugene Dempsey
, Adelina Pellicer
, Afif EL-Khuffash
, Shashidhar A
, Salvador Piris-Borregas
, Miguel Alsina
, Merih Cetinkaya
, Lina Chalak
, Hilal Özkan
, Mariana Baserga
, Jan Sirc
, Hans Fuchs
, Ebru Ergenekon
, Luis Arruza
, Amit Mathur
, Martin Stocker
, Olalla Otero Vaccarello

Tomasz Szczapa, Kosmas Sarafidis, Barbara Królak-Olejnik, Asli Memisoglu, Hallvard Reigstad, Elżbieta Rafińska-Ważny, Eleftheria Hatzidaki, Zhang Peng, Despoina Gkentzi, Renaud Viellevoye, Julie De Buyst, Emmanuele Mastretta, Ping Wang, Gitte Holst Hahn, Lars Bender, Luc Cornette, Jakub Tkaczyk, Ruth del Rio, Monica Fumagalli, Evangelia Papathoma, Maria Wilinska, Gunnar Naulaers, Iwona Sadowska-Krawczenko, Chantal Lecart, María Luz Couce, Siv Fredly, Anne Marie Heuchan, Tanja Karen, Gorm Greisen

University of Copenhagen
Medical University of Graz
Hospital Universitario La Paz
Royal College of Surgeons in Ireland
St. John's National Academy of Health Sciences
Hospital Universitario 12 de Octubre
Hospital Clínic de Barcelona
Kanuni Sultan Suleyman Training and Research Hospital
University of Texas Southwestern Medical Center
Uludag University
University of Utah
Charles University
University of Freiburg
Gazi University
Hospital Clínico San Carlos de Madrid
Saint Louis University
Children's Hospital Lucerne
Hospital Joan XXIII
University of Medical Sciences Poznan
Aristotle University of Thessaloniki
Wrocław Medical University
Marmara University
University of Bergen
Centrum Medyczne “Ujastek”
Heraklion University Hospital
Children's Hospital of Fudan University
University of Patras
University of Liege
Tivoli Hospital
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Guangzhou Women and Children's Medical Center
Aalborg University
General Hospital St. Jan
SJD Barcelona Children's Hospital
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
University of Milan
Alexandra University and State Maternity Hospital
Medical Centre for Postgraduate Education, Warsaw
KU Leuven
Nicolaus Copernicus University in Toruń
Grand Hôpital de Charleroi (GHdC)
Complejo Hospitalario Universitario de Santiago
University of Oslo
NHS Greater Glasgow and Clyde
University of Zurich

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (−6.6%, 95% CI −18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.

Original language	English
Article number	647880
Journal	Frontiers in Pediatrics
Volume	9
DOIs	https://doi.org/10.3389/fped.2021.647880
Publication status	Published - 12 Jul 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
extremely preterm
neonatal intensive care unit admission
observational study
pandemic
randomized clinical trial

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10.3389/fped.2021.647880

Cite this

Rasmussen, M. I., Hansen, M. L., Pichler, G., Dempsey, E., Pellicer, A., EL-Khuffash, A., A, S., Piris-Borregas, S., Alsina, M., Cetinkaya, M., Chalak, L., Özkan, H., Baserga, M., Sirc, J., Fuchs, H., Ergenekon, E., Arruza, L., Mathur, A., Stocker, M., ... Greisen, G. (2021). Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown. Frontiers in Pediatrics, 9, Article 647880. https://doi.org/10.3389/fped.2021.647880

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title = "Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown",

abstract = "Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58\%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (−6.6\%, 95\% CI −18.2 to +7.1\%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3\%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.",

keywords = "COVID-19, extremely preterm, neonatal intensive care unit admission, observational study, pandemic, randomized clinical trial",

author = "Rasmussen, \{Marie Isabel\} and Hansen, \{Mathias L{\"u}hr\} and Gerhard Pichler and Eugene Dempsey and Adelina Pellicer and Afif EL-Khuffash and Shashidhar A and Salvador Piris-Borregas and Miguel Alsina and Merih Cetinkaya and Lina Chalak and Hilal {\"O}zkan and Mariana Baserga and Jan Sirc and Hans Fuchs and Ebru Ergenekon and Luis Arruza and Amit Mathur and Martin Stocker and \{Otero Vaccarello\}, Olalla and Tomasz Szczapa and Kosmas Sarafidis and Barbara Kr{\'o}lak-Olejnik and Asli Memisoglu and Hallvard Reigstad and El{\.z}bieta Rafi{\'n}ska-Wa{\.z}ny and Eleftheria Hatzidaki and Zhang Peng and Despoina Gkentzi and Renaud Viellevoye and \{De Buyst\}, Julie and Emmanuele Mastretta and Ping Wang and Hahn, \{Gitte Holst\} and Lars Bender and Luc Cornette and Jakub Tkaczyk and \{del Rio\}, Ruth and Monica Fumagalli and Evangelia Papathoma and Maria Wilinska and Gunnar Naulaers and Iwona Sadowska-Krawczenko and Chantal Lecart and Couce, \{Mar{\'i}a Luz\} and Siv Fredly and Heuchan, \{Anne Marie\} and Tanja Karen and Gorm Greisen",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Rasmussen, Hansen, Pichler, Dempsey, Pellicer, EL-Khuffash, A, Piris-Borregas, Alsina, Cetinkaya, Chalak, {\"O}zkan, Baserga, Sirc, Fuchs, Ergenekon, Arruza, Mathur, Stocker, Otero Vaccarello, Szczapa, Sarafidis, Kr{\'o}lak-Olejnik, Memisoglu, Reigstad, Rafi{\'n}ska-Wa{\.z}ny, Hatzidaki, Peng, Gkentzi, Viellevoye, De Buyst, Mastretta, Wang, Hahn, Bender, Cornette, Tkaczyk, del Rio, Fumagalli, Papathoma, Wilinska, Naulaers, Sadowska-Krawczenko, Lecart, Couce, Fredly, Heuchan, Karen and Greisen.",

year = "2021",

month = jul,

day = "12",

doi = "10.3389/fped.2021.647880",

language = "English",

volume = "9",

journal = "Frontiers in Pediatrics",

issn = "2296-2360",

publisher = "Frontiers Media SA",

}

Rasmussen, MI, Hansen, ML, Pichler, G, Dempsey, E, Pellicer, A, EL-Khuffash, A, A, S, Piris-Borregas, S, Alsina, M, Cetinkaya, M, Chalak, L, Özkan, H, Baserga, M, Sirc, J, Fuchs, H, Ergenekon, E, Arruza, L, Mathur, A, Stocker, M, Otero Vaccarello, O, Szczapa, T, Sarafidis, K, Królak-Olejnik, B, Memisoglu, A, Reigstad, H, Rafińska-Ważny, E, Hatzidaki, E, Peng, Z, Gkentzi, D, Viellevoye, R, De Buyst, J, Mastretta, E, Wang, P, Hahn, GH, Bender, L, Cornette, L, Tkaczyk, J, del Rio, R, Fumagalli, M, Papathoma, E, Wilinska, M, Naulaers, G, Sadowska-Krawczenko, I, Lecart, C, Couce, ML, Fredly, S, Heuchan, AM, Karen, T & Greisen, G 2021, 'Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown', Frontiers in Pediatrics, vol. 9, 647880. https://doi.org/10.3389/fped.2021.647880

TY - JOUR

T1 - Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

AU - Rasmussen, Marie Isabel

AU - Hansen, Mathias Lühr

AU - Pichler, Gerhard

AU - Dempsey, Eugene

AU - Pellicer, Adelina

AU - EL-Khuffash, Afif

AU - A, Shashidhar

AU - Piris-Borregas, Salvador

AU - Alsina, Miguel

AU - Cetinkaya, Merih

AU - Chalak, Lina

AU - Özkan, Hilal

AU - Baserga, Mariana

AU - Sirc, Jan

AU - Fuchs, Hans

AU - Ergenekon, Ebru

AU - Arruza, Luis

AU - Mathur, Amit

AU - Stocker, Martin

AU - Otero Vaccarello, Olalla

AU - Szczapa, Tomasz

AU - Sarafidis, Kosmas

AU - Królak-Olejnik, Barbara

AU - Memisoglu, Asli

AU - Reigstad, Hallvard

AU - Rafińska-Ważny, Elżbieta

AU - Hatzidaki, Eleftheria

AU - Peng, Zhang

AU - Gkentzi, Despoina

AU - Viellevoye, Renaud

AU - De Buyst, Julie

AU - Mastretta, Emmanuele

AU - Wang, Ping

AU - Hahn, Gitte Holst

AU - Bender, Lars

AU - Cornette, Luc

AU - Tkaczyk, Jakub

AU - del Rio, Ruth

AU - Fumagalli, Monica

AU - Papathoma, Evangelia

AU - Wilinska, Maria

AU - Naulaers, Gunnar

AU - Sadowska-Krawczenko, Iwona

AU - Lecart, Chantal

AU - Couce, María Luz

AU - Fredly, Siv

AU - Heuchan, Anne Marie

AU - Karen, Tanja

AU - Greisen, Gorm

N1 - Publisher Copyright: © Copyright © 2021 Rasmussen, Hansen, Pichler, Dempsey, Pellicer, EL-Khuffash, A, Piris-Borregas, Alsina, Cetinkaya, Chalak, Özkan, Baserga, Sirc, Fuchs, Ergenekon, Arruza, Mathur, Stocker, Otero Vaccarello, Szczapa, Sarafidis, Królak-Olejnik, Memisoglu, Reigstad, Rafińska-Ważny, Hatzidaki, Peng, Gkentzi, Viellevoye, De Buyst, Mastretta, Wang, Hahn, Bender, Cornette, Tkaczyk, del Rio, Fumagalli, Papathoma, Wilinska, Naulaers, Sadowska-Krawczenko, Lecart, Couce, Fredly, Heuchan, Karen and Greisen.

PY - 2021/7/12

Y1 - 2021/7/12

N2 - Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (−6.6%, 95% CI −18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.

AB - Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (−6.6%, 95% CI −18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.

KW - COVID-19

KW - extremely preterm

KW - neonatal intensive care unit admission

KW - observational study

KW - pandemic

KW - randomized clinical trial

UR - https://www.scopus.com/pages/publications/85111256604

U2 - 10.3389/fped.2021.647880

DO - 10.3389/fped.2021.647880

M3 - Article

AN - SCOPUS:85111256604

SN - 2296-2360

VL - 9

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

M1 - 647880

ER -

Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

Abstract

UN SDGs

Keywords

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