Fabrication of a Gold Dual-microelectrode Patterned on a Silicone Substrate Probe for the Discrimination of Different Tissues

A gold dual-microelectrode probe patterned on a silicon substrate for bio-impedance measurement was fabricated, characterised and tested on different types of tissues. The aim of this study is to fabricate a device capable of using bioimpedance to discriminate different tissue types. This proof of concept of the device was characterised on meat and a gel/lard phantom which mimics fat and muscle. The initial results demonstrated that the gold dual-microelectrode probe had excellent electrochemical recording potential. The bio-impedance data derived was capable of differentiation between biological tissues. Bio-impedance measurement may enhance cancer diagnostics by providing novel data in relation to cancer and surrounding healthy tissue. This manuscript describes the design, fabrication and validation of a gold dual-microelectrode bioimpedance sensor with a potential future application in cancer diagnostics.